{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:48:22Z","timestamp":1760888902027,"version":"3.40.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T00:00:00Z","timestamp":1401148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the possible relationship between angiotensin\u2010converting enzyme (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>) gene polymorphism (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>genotypes) and respiratory distress syndrome (<jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>) in preterm neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Our study included 120 preterm neonates (&lt;37 weeks of gestation) with<jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>(the patient group) and 120 preterm neonates without<jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>(the control group). Blood samples were obtained from patients and control groups, and<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>gene polymorphism was analysed using the polymerase chain reaction method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>genotype was highly significant in the patient group compared with the control group (48.3% of<jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>group vs 20% of the control group,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Meanwhile,<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>genotypes were significantly higher in the control group (75% and 5% of the control group vs 50% and 1.7% of the patient group,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>genotype was highly significant in neonates with bronchopulmonary dysplasia (<jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content>) compared with<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>genotype (<jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results may suggest that<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>genotype is associated with increased risk of<jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content>development in preterm neonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12161","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T10:41:39Z","timestamp":1399372899000},"page":"450-456","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between angiotensin\u2010converting enzyme gene polymorphism and respiratory distress syndrome in premature neonates"],"prefix":"10.1111","volume":"9","author":[{"given":"Nouran 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