{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:03:19Z","timestamp":1782363799177,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Quality of life in patients with non\u2010cystic fibrosis (non\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) bronchiectasis is largely defined by respiratory symptoms. To date, no disease\u2010specific tool for symptom measurement in this patient group was available. We developed the lower respiratory tract infections \u2013 visual analogue scale (<jats:styled-content style=\"fixed-case\">LRTI\u2010VAS<\/jats:styled-content>) in order to quickly and conveniently quantify symptoms in non\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> bronchiectasis. This study aimed to validate <jats:styled-content style=\"fixed-case\">LRTI\u2010VAS<\/jats:styled-content> for use in non\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> bronchiectasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included outpatients with radiologically proven bronchiectasis and no evidence of <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. Results of <jats:styled-content style=\"fixed-case\">LRTI\u2010VAS<\/jats:styled-content> were compared with other markers of disease activity {lung function parameters, oxygen saturation and three health\u2010related quality of life questionnaires [<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>utcomes <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tudy <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>hort\u2010<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>orm 36 <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>urvey (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036), <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>t <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>eorges <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>espiratory <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire (<jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eicester <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ough <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire (<jats:styled-content style=\"fixed-case\">LCQ<\/jats:styled-content>)]} and validity, reliability and responsiveness were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty stable and 30 exacerbating participants completed the <jats:styled-content style=\"fixed-case\">LRTI\u2010VAS<\/jats:styled-content> questionnaire. When testing for repeatability on two separate occasions, no statistically significant difference between total scores was found {1.4 [standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>)] 5.3}, <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.16). Internal consistency was high across items (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ronbach's alpha 0.86). Correlation with <jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 and <jats:styled-content style=\"fixed-case\">LCQ<\/jats:styled-content> total scores was high. Following antibiotic treatment, mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">LRTI\u2010VAS<\/jats:styled-content> total score improved from 18.1 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 9.9) to 26.1 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 6.6) (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LRTI\u2010VAS<\/jats:styled-content> showed excellent validity, reliability and responsiveness to change and therefore appears a reliable tool for symptom measurement in non\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> bronchiectasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12198","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T09:30:06Z","timestamp":1407490206000},"page":"168-175","source":"Crossref","is-referenced-by-count":19,"title":["Validation of a visual analogue score (<scp>LRTI\u2010VAS<\/scp>) in non\u2010<scp>CF<\/scp> bronchiectasis"],"prefix":"10.1111","volume":"10","author":[{"given":"Josje","family":"Altenburg","sequence":"first","affiliation":[{"name":"Department of Pulmonary Diseases Alkmaar Medical Centre  Alkmaar the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Wortel","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Alkmaar Medical Centre  Alkmaar the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper S.","family":"de Graaff","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Alkmaar Medical Centre  Alkmaar the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tjip S.","family":"van der Werf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Medical Centre Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim G.","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Alkmaar Medical Centre  Alkmaar the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,4]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"De l'Auscultation M\u00e9diate ou Trait\u00e9 du Diagnostic des Maladies des Poumons et du Coeur","author":"Laennec RTH","year":"1819"},{"key":"e_1_2_7_3_1","first-page":"6","article-title":"Inflammation: a two\u2010edged sword \u2013 the model of bronchiectasis","volume":"147","author":"Cole PJ","year":"1986","journal-title":"Eur J Respir Dis Suppl"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9906120"},{"key":"e_1_2_7_5_1","unstructured":"AltenburgJ WortelK deGraaffCS BoersmaWG.Time to diagnosis and adherence to guidelines in a large cohort of patients with non\u2010CF bronchiectasis. 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