{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:52:37Z","timestamp":1776873157729,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The solitary pulmonary nodule (<jats:styled-content style=\"fixed-case\">SPN<\/jats:styled-content>) is a common clinical problem usually detected incidentally during screening tests for lung cancer. Video\u2010assisted thoracoscopic surgery (<jats:styled-content style=\"fixed-case\">VATS<\/jats:styled-content>) is performed for diagnosing <jats:styled-content style=\"fixed-case\">SPNs<\/jats:styled-content> when there are technical difficulties with transthoracic needle aspiration biopsy or bronchoscopic biopsy, inconclusive biopsy results, or when there is a high suspicion of malignancy. This study aimed to identify factors that can reduce unnecessary <jats:styled-content style=\"fixed-case\">VATS<\/jats:styled-content> for the diagnosis of <jats:styled-content style=\"fixed-case\">SPNs<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed patients with <jats:styled-content style=\"fixed-case\">SPNs<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u2009107) who had undergone diagnostic <jats:styled-content style=\"fixed-case\">VATS<\/jats:styled-content> at <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>eoul <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital from <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2007 to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2008. Clinical and radiological parameters were evaluated to compare benign and malignant <jats:styled-content style=\"fixed-case\">SPNs<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Benign <jats:styled-content style=\"fixed-case\">SPNs<\/jats:styled-content> were diagnosed in 31 patients (29.0%). The most common reason for patients to undergo a diagnostic <jats:styled-content style=\"fixed-case\">VATS<\/jats:styled-content> was a history of malignancy. The most common histological findings in patients with benign <jats:styled-content style=\"fixed-case\">SPNs<\/jats:styled-content> were non\u2010specific inflammatory lesions (29.0%) and tuberculosis (16.1%). The presence of respiratory symptoms was significantly associated with benign diseases [<jats:italic>P<\/jats:italic>\u2009=\u20090.004, odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 0.189, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.060\u20130.590], and part\u2010solid nodules were significantly related to malignancy (<jats:italic>P<\/jats:italic>\u2009=\u20090.026, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.34, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.248\u201332.169).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Approximately 30% of <jats:styled-content style=\"fixed-case\">SPNs<\/jats:styled-content> resected by <jats:styled-content style=\"fixed-case\">VATS<\/jats:styled-content> were benign. Although we did not identify a definite factor for predicting benign disease or malignancy, the presence of respiratory symptoms was related to benign disease, and part\u2010solid nodules were associated with malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12200","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T09:30:18Z","timestamp":1407490218000},"page":"181-188","source":"Crossref","is-referenced-by-count":15,"title":["Characteristics of benign solitary pulmonary nodules confirmed by diagnostic video\u2010assisted thoracoscopic surgery"],"prefix":"10.1111","volume":"10","author":[{"given":"Sun Mi","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Heo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul Metropolitan Government\u2010Seoul National University Boramae Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sik","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul National University Hospital  Seoul 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