{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:14:54Z","timestamp":1784355294960,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Background and Aims<\/jats:title>Our aim was to investigate whether neurological alteration in patients with obstructive sleep apnoea syndrome (OSAS<\/jats:styled-content>) with apparently normal cerebral and cerebellar structures can be assessed by means of apparent diffusion coefficient (ADC<\/jats:styled-content>) measurement and to investigate the association between OSAS<\/jats:styled-content> severity and ADC<\/jats:styled-content> values.<\/jats:p><\/jats:sec>Methods<\/jats:title>Following the acquisition of diffusion\u2010weighted cranial magnetic resonance imaging, ADC<\/jats:styled-content> measurements were performed in 24 different apparently normal cerebral and cerebellar structures, including the bilateral frontal and parietal cortices, insulae, cingulate gyri, hippocampi, frontal and parieto\u2010occipital periventricular white matter (PWM<\/jats:styled-content>), caudate nuclei, putamen, thalami, cerebellar hemispheres, pons and mesencephalon in 47 OSAS<\/jats:styled-content> patients and 20 control subjects. The ADC<\/jats:styled-content> values of the patients and the control group were compared. The association between the apnoea\u2013hypopnoea index (AHI<\/jats:styled-content>) and the ADC<\/jats:styled-content> values of the patients were investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>The ADC<\/jats:styled-content> values in the bilateral frontal PWM<\/jats:styled-content> were lower in the patient group than those in the control subjects (P<\/jats:italic>\u2009<\u20090.05). The measurements in the right cingulate gyri of the OSAS<\/jats:styled-content> patients exhibited significantly higher ADC<\/jats:styled-content> values than those of the control group (P<\/jats:italic>\u2009=\u20090.002). Bilateral thalamic ADC<\/jats:styled-content> values in severe OSAS<\/jats:styled-content> patients were significantly higher than those in mild and moderate OSAS<\/jats:styled-content> patients (P<\/jats:italic>\u2009<\u20090.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The ADC<\/jats:styled-content> measurement is a simple and effective technique to evaluate neural alteration of the brain in patients with OSAS<\/jats:styled-content>. ADC<\/jats:styled-content> measurements can also be useful in the evaluation of the association between the AHI<\/jats:styled-content> and the degree of neural alteration in the central nervous system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12201","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T09:30:25Z","timestamp":1407490225000},"page":"189-197","source":"Crossref","is-referenced-by-count":5,"title":["Assessment of neural alterations in obstructive sleep apnoea syndrome: can apparent diffusion coefficient measurements be useful?"],"prefix":"10.1111","volume":"10","author":[{"given":"Emre","family":"Kacar","sequence":"first","affiliation":[{"name":"Department of Radiology School of Medicine Afyon Kocatepe University Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevinc","family":"Sarinc Ulasli","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine School of Medicine Afyon 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