{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T14:10:07Z","timestamp":1746367807079,"version":"3.40.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The appropriate treatment of pandemic<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>influenza which was first identified in<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2009 in<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>exico is insufficient especially for immunocompromised patients. We aimed to evaluate the features and prognostic factors of the children with<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>, especially immunocompromised ones, and whether intravenous immunoglobulin<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>) replacement could aid for a better outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one hospitalized children with laboratory\u2010confirmed<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>were evaluated retrospectively. Data were extracted from files and electronic medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 37 (1\u2013216) months; 62% of them were under 5\u2009years of age and 71.4% had one or more underlying disorders. Main symptoms were high fever, cough, fatigue and vomiting. Lower respiratory tract manifestations were seen in 66.6% of children. Mortality rate was 4.7%. The patient who died had the lowest lymphocyte (100\/mm<jats:sup>3<\/jats:sup>), thrombocyte (21\u2009000\/mm<jats:sup>3<\/jats:sup>) and highest blood urea nitrogen (87\u2009mg\/d<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>) levels. Fifty\u2010eight percent of evaluated patients had one of the primary immunodeficiency disorders. Surprisingly, none of the six patients with primary immunodeficiency who are on regular<jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>replacement needed intensive care unit and died. Although median durations of cough, fever and hospitalization were lower, they did not change statistically according to get<jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>replacement regularly (<jats:italic>P<\/jats:italic>\u2009=\u20090.47, 0.97, 0.09, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study is important while it is the first one that shows the course of primary immunodeficient children with<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>infection who were on regular<jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>replacement. A trial of high\u2010dose<jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>may be a useful adjunctive therapy in severe<jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content>influenza, particularly in the immunocompromised patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12209","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T05:46:08Z","timestamp":1409895968000},"page":"223-230","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of intravenous immunoglobulin treatment in immunocompromised children with<scp>H1N1<\/scp>influenza: a clinical observation"],"prefix":"10.1111","volume":"10","author":[{"given":"Bahar","family":"Gokturk","sequence":"first","affiliation":[{"name":"Department of Pediatric Immunology and Allergy Konya Training and Research Hospital Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi","family":"Pekcan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology Department of Pediatrics Necmettin Erbakan University Meram Medical Faculty Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukru Nail","family":"Guner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Immunology Department of Pediatrics Necmettin Erbakan University Meram Medical Faculty Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasibe","family":"Artac","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Immunology Department of Pediatrics Selcuk University Medical Faculty Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi","family":"Keles","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Immunology Department of Pediatrics Necmettin Erbakan University Meram Medical Faculty Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine","family":"Kirac","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Immunology Department of Pediatrics Necmettin Erbakan University Meram Medical Faculty Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Reisli","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Immunology Department of Pediatrics Necmettin Erbakan University Meram Medical Faculty Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"244","article-title":"Influenza, an existing public health problem","volume":"48","author":"Garcia\u2010Garcia J","year":"2006","journal-title":"Salud Publica Mex"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268809002088"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/515616"},{"key":"e_1_2_6_5_1","first-page":"2605","article-title":"Emergence of a novel swine\u2010origin influenza A (H1N1) virus in humans","volume":"18","author":"Novel Swine\u2010Origin Influenza A (H1N1) Virus Investigation Team","year":"2009","journal-title":"N Engl J Med"},{"key":"e_1_2_6_6_1","unstructured":"The Ministry of Health of Turkey.Pandemic influenza A (H1N1) bulletin. 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