{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T17:52:54Z","timestamp":1723485174564},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shanghai Minhang District","award":["2013MHZ022"],"award-info":[{"award-number":["2013MHZ022"]}]},{"name":"Shanghai Committee of Science and Technology","award":["No. 134119b1200"],"award-info":[{"award-number":["No. 134119b1200"]}]},{"name":"Outstanding Academic Leader of Health System in Shanghai","award":["XBR2013078"],"award-info":[{"award-number":["XBR2013078"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Abstract<\/jats:title>Background and Aims<\/jats:title>Lung cancer is a multifactorial disease. Xeroderma pigmentosum group D<\/jats:styled-content> (XPD<\/jats:italic><\/jats:styled-content>) and X<\/jats:styled-content>\u2010ray repair cross\u2010complementing 1 (XRCC1<\/jats:italic><\/jats:styled-content>) genes are 2 important susceptibility genes related to lung cancer. In this study, we explored the correlation between genetic polymorphisms in XPD<\/jats:italic><\/jats:styled-content> and XRCC1<\/jats:italic><\/jats:styled-content> and the risk of non\u2010small cell lung cancer (NSCLC<\/jats:styled-content>) in the E<\/jats:styled-content>ast C<\/jats:styled-content>hinese H<\/jats:styled-content>an population. We also investigated risk factors associated with non\u2010small cell lung cancer in this population.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a case control study in 120 NSCLC<\/jats:styled-content> patients and 120 healthy controls. The NSCLC<\/jats:styled-content> patients were further divided into three subgroups, squamous carcinoma, adenocarcinoma and other type of cancer, according to tumor histology. No patients had undergone any treatment. Polymerase chain reaction and restriction fragment length polymorphism technologies were applied to detect the distribution of XPD\u2010751<\/jats:italic><\/jats:styled-content>, XRCC1\u2010194<\/jats:italic><\/jats:styled-content> and XRCC1\u2010399<\/jats:italic><\/jats:styled-content> genes in all patients.<\/jats:p><\/jats:sec>Results<\/jats:title>The results showed significant gene frequency differences for all three genes between patients with NSCLC<\/jats:styled-content> and control patients. Significantly different frequencies of XPD<\/jats:styled-content>\u2010751\u2010G<\/jats:styled-content>ln, XRCC<\/jats:styled-content>\u2010194\u2010T<\/jats:styled-content>rp and XRCC<\/jats:styled-content>1\u2010399\u2010Gln mutant alleles were observed between the two groups. XPD<\/jats:styled-content>\u2010751SNP<\/jats:styled-content> and XRCC<\/jats:styled-content>1\u2010194SNP<\/jats:styled-content> frequencies varied among the three lung cancer groups, while the frequency of XRCC<\/jats:styled-content>1\u2010399SNP<\/jats:styled-content> did not differ significantly.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The results suggested that genetic polymorphisms in XPD\u2010751<\/jats:italic><\/jats:styled-content>, XRCC1\u2010194<\/jats:italic><\/jats:styled-content> and XRCC1\u2010399<\/jats:italic><\/jats:styled-content> were related to the risk of NSCLC<\/jats:styled-content>, among which XPD<\/jats:styled-content>\u2010751SNP<\/jats:styled-content> was responsible for adenocarcinoma, while XRCC<\/jats:styled-content>1\u2010194SNP<\/jats:styled-content> was closely linked to squamous carcinoma. Smoking and XRCC<\/jats:styled-content>1\u2010194SNP<\/jats:styled-content> were risk factors of NSCLC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12218","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T08:01:52Z","timestamp":1413187312000},"page":"311-317","source":"Crossref","is-referenced-by-count":13,"title":["Association between genetic polymorphisms in XPD<\/i><\/scp> and XRCC1<\/i><\/scp> genes and risks of non\u2010small cell lung cancer in E<\/scp>ast C<\/scp>hinese H<\/scp>an population"],"prefix":"10.1111","volume":"10","author":[{"given":"Yong","family":"Du","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine The Fifth People's Hospital of Shanghai Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The Fifth People's Hospital of Shanghai Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhoufang","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The Fifth People's Hospital of Shanghai Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The Fifth People's Hospital of Shanghai Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jindong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The Fifth People's Hospital of Shanghai Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijun","family":"Jie","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The Fifth People's Hospital of Shanghai Fudan University Shanghai 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