{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:03:10Z","timestamp":1778706190250,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Tuberculosis is a major global health problem. However, anti\u2010tuberculosis drug treatment has many adverse effects, such as drug\u2010caused fever. The aim of this study was to investigate the clinical features and treatments of anti\u2010tuberculosis drugs\u2010induced fever.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 78 inpatients and outpatients with pulmonary tuberculosis accompanied by drug fever during the anti\u2010tuberculosis treatment were analysed retrospectively from <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2006 to <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the anti\u2010tuberculosis drugs that caused the drug fever, rifampicin was the most common one, followed by para\u2010aminosalicylic and pyrazinamide. The symptoms occurred within 2 months after treatment, mainly in the 1\u20133 weeks, and the main symptom was high fever with body temperature above 39\u00b0<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>. The accompanying symptoms include rash, chills, headache, stuffy nose, runny nose, nausea, vomiting and joint pain. Routine blood examination found that eosinophilia increased in 15 cases and decreased in another 15. Among 63 patients who underwent liver function tests, there were 10 cases of abnormal function and 4 cases of liver damage. When the drug fever was suspected, the measure of withdrawal was taken first. All the suspected drugs were withdrawn in 59 cases, while gradual withdrawal was conducted in 19 cases. Patients with complications were first treated in accordance with the principles of complications treatment and then were gradually given some drugs after recovery. The patients without complications were gradually given some drugs after the body temperature was back to normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Drug fever is an allergic reaction, the resolution of which depends on whether it was accompanied by liver damage and\/or rash or not.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12242","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T08:53:29Z","timestamp":1416214409000},"page":"449-454","source":"Crossref","is-referenced-by-count":9,"title":["Clinical features and treatment of drug fever caused by anti\u2010tuberculosis drugs"],"prefix":"10.1111","volume":"10","author":[{"given":"Yong","family":"Fang","sequence":"first","affiliation":[{"name":"Tuberculosis Center for Diagnosis and Treatment Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai Key Lab of Tuberculosis  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heping","family":"Xiao","sequence":"additional","affiliation":[{"name":"Tuberculosis Center for Diagnosis and Treatment Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai Key Lab of Tuberculosis  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenjie","family":"Tang","sequence":"additional","affiliation":[{"name":"Tuberculosis Center for Diagnosis and Treatment Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai Key Lab of Tuberculosis  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liang","sequence":"additional","affiliation":[{"name":"Tuberculosis Center for Diagnosis and Treatment Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai Key Lab of Tuberculosis  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sha","sequence":"additional","affiliation":[{"name":"Tuberculosis Center for Diagnosis and Treatment Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai Key Lab of Tuberculosis  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Tuberculosis Center for Diagnosis and Treatment Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai Key Lab of Tuberculosis  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_2_4_2_1","unstructured":"World Health Organization.Global Tuberculosis Report 2013. 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