{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:49:28Z","timestamp":1782485368953,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metastatic lesions in the large bowel are rare. A case of single symptomatic colonic metastasis as first presentation of pulmonary mucoepidermoid carcinoma (MEC) is described. A 62\u2010year\u2010old male was admitted with constipation and rectal bleeding. Colonoscopy revealed extrinsic compression at sigmoid colon, and microscopy suggested a secondary origin. Subsequent chest computed tomography confirmed a right perihilar mass invading posterior mediastinum, carina and esophagus, and also a second consolidation on right lower lobe and ipsilateral mediastinal and subcarinal lymph nodes. After pathologic evaluation of a transthoracic biopsy specimen, the diagnosis of pulmonary high\u2010grade MEC, stage IV (T4, N3, M1b \u2013 7th ed. TNM), was established. Chemotherapy with carboplatin and paclitaxel was initiated, and disease progression occurred after two cycles with increasing colonic mass. Palliative surgery was rejected because of advanced stage, and the patient was submitted to palliative pelvic radiotherapy. Second\u2010line chemotherapy with gemcitabine was initiated, but clinical status worsened and the patient died because of severe lung failure. Clinical, pathological and therapeutic aspects of this uncommon site of extrathoracic metastatic disease are discussed, emphasizing the important contribution of special stains and immunohistochemistry to the diagnosis.<\/jats:p>","DOI":"10.1111\/crj.12251","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T07:24:15Z","timestamp":1419319455000},"page":"524-529","source":"Crossref","is-referenced-by-count":4,"title":["Single symptomatic colonic metastasis as first presentation of a pulmonary mucoepidermoid carcinoma"],"prefix":"10.1111","volume":"10","author":[{"given":"In\u00eas","family":"Franco","sequence":"first","affiliation":[{"name":"Department of Pulmonology Centro Hospitalar Vila Nova de Gaia\/Espinho  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tente","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Centro Hospitalar Vila Nova de Gaia\/Espinho  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Centro Hospitalar Vila Nova de Gaia\/Espinho  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Linhas","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Centro Hospitalar Vila Nova de Gaia\/Espinho  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Antunes","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Centro Hospitalar Vila Nova de Gaia\/Espinho  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Barroso","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Centro Hospitalar Vila Nova de Gaia\/Espinho  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1208"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i38.4314"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820101)49:1<170::AID-CNCR2820490134>3.0.CO;2-A"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1907"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i9.1399"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.5481"},{"issue":"3","key":"e_1_2_4_8_1","first-page":"199","article-title":"Colonic metastasis from bronchogenic carcinoma presenting as pancolitis","volume":"48","author":"John AK","year":"2002","journal-title":"J Postgrad Med"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(01)00646-7"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-10-232"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-6-132"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327480601300406"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23048"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.72"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.09.007"},{"issue":"5","key":"e_1_2_4_16_1","first-page":"426","article-title":"[Positron emission tomography (PET)\u2010computed tomography (CT) suggesting small intestinal metastasis from lung cancer; report of a case]","volume":"59","author":"Shiono S","year":"2006","journal-title":"Kyobu Geka"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.778"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.3354"},{"issue":"4","key":"e_1_2_4_19_1","first-page":"iv23","article-title":"18F\u2010Fluoro\u20102\u2010deoxyglucose positron emission tomography in the evaluation of gastrointestinal malignancies","volume":"52","author":"Chin BB","year":"2003","journal-title":"Gut"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.10.116"},{"issue":"2","key":"e_1_2_4_21_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5858\/134.2.207","article-title":"Diagnosis of metastatic neoplasms: an immunohistochemical approach","volume":"134","author":"Krishna M","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1488-z"},{"issue":"6","key":"e_1_2_4_23_1","first-page":"290","article-title":"Intestinal metastases of bronchopulmonary cancer. 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