{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:35Z","timestamp":1787014055484,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims<\/jats:title>\n \n It is not yet known if transbronchial cryobiopsy (\n TCB<\/jats:styled-content>\n ) is a reliable and safe diagnostic tool in the investigation of interstitial lung disease (\n ILD<\/jats:styled-content>\n ). To date, there have been no studies directly comparing the value of\n TCB<\/jats:styled-content>\n with that of surgical lung biopsy (\n SLB<\/jats:styled-content>\n ). The study was initiated to determine whether the samples taken by\n TCB<\/jats:styled-content>\n lead to a reliable diagnosis and whether\n SLB<\/jats:styled-content>\n can be avoided in a relevant percentage of cases.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We analyzed 32 subjects with suspected\n ILD<\/jats:styled-content>\n who underwent a\n TCB<\/jats:styled-content>\n . Subjects' baseline characteristics, pathological findings after\n TCB<\/jats:styled-content>\n and\n SLB<\/jats:styled-content>\n , and complication rates were analyzed. The pathological inter\u2010rater agreement was quantified statistically.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The overall inter\u2010rater agreement concerning\n TCB<\/jats:styled-content>\n sample evaluation was good with a kappa value of 0.80. In 23\/32 cases (72%), the findings from the\n TCB<\/jats:styled-content>\n showed a strong congruence with all other clinical data, thereby enabling a definitive diagnosis. Eight of the remaining nine subjects gave their consent for an\n SLB<\/jats:styled-content>\n , which led to a definitive histological diagnosis in six cases (75%). Following\n TCB<\/jats:styled-content>\n , pneumothorax occurred in 6\/32 subjects (19%) and endobronchial bleeding was moderate in 8\/32 (25%) and was severe in 17\/32 cases (53%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This is the first study to correlate histological results and complications following\n TCB<\/jats:styled-content>\n and\n SLB<\/jats:styled-content>\n in\n ILD<\/jats:styled-content>\n subjects, some of whom underwent both procedures.\n TCB<\/jats:styled-content>\n is a suitable diagnostic tool in\n ILD<\/jats:styled-content>\n , potentially completely dispensing with the need for an\n SLB<\/jats:styled-content>\n in some cases. In all cases, an interdisciplinary case evaluation is necessary as a final step.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/crj.12261","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T04:12:28Z","timestamp":1422245548000},"page":"589-595","source":"Crossref","is-referenced-by-count":72,"title":["The role of transbronchial cryobiopsy and surgical lung biopsy in the diagnostic algorithm of interstitial lung disease"],"prefix":"10.1111","volume":"10","author":[{"given":"Lars","family":"Hagmeyer","sequence":"first","affiliation":[{"name":"Clinic for Pneumology and Allergology Center of Sleep Medicine and Respiratory Care Bethanien Hospital Solingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Theegarten","sequence":"additional","affiliation":[{"name":"Institute for Pathology and Neuropathology University Hospital Essen University Duisburg\u2010Essen Duisburg\u2010Essen 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Sleep Medicine and Respiratory Care Bethanien Hospital Solingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried J.","family":"Randerath","sequence":"additional","affiliation":[{"name":"Clinic for Pneumology and Allergology Center of Sleep Medicine and Respiratory Care Bethanien Hospital Solingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00492002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2010.02528.x"},{"key":"e_1_2_7_6_1","first-page":"36","article-title":"The role of transbronchial lung biopsy for the diagnosis of diffuse drug\u2010induced lung disease: a case series 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