{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:13:03Z","timestamp":1790255583543,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fujian Province of China","award":["2014J01414"],"award-info":[{"award-number":["2014J01414"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Excessive daytime sleepiness (EDS<\/jats:styled-content>), which is commonly considered a cardinal sign of obstructive sleep apnea (OSA<\/jats:styled-content>), may lead to an increased rate of metabolic syndrome (MetS<\/jats:styled-content>), and be an independent risk factor for cardiovascular morbidity and mortality. The aim of this cross\u2010sectional study was to examine the role of EDS<\/jats:styled-content> in MetS<\/jats:styled-content> and its components by researching severe OSA<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>The records of 175 consecutive patients who underwent standard polysomnography and diagnosed severe OSA<\/jats:styled-content> were included. Subjective daytime sleepiness was assessed using the E<\/jats:styled-content>pworth sleepiness scale (ESS<\/jats:styled-content>). Fasting glucose, lipids, insulin and polysomnography parameters were measured. A metabolic score was counted as the total number of the positive diagnostic criteria of MetS<\/jats:styled-content> for each subject, which indicated the level of metabolic disorder.<\/jats:p><\/jats:sec>Results<\/jats:title>The prevalence of central obesity, hypertriglyceridemia, low high density lipoprotein\u2010cholesterol and MetS<\/jats:styled-content> (78.2% vs 28.6%) was significantly higher among EDS<\/jats:styled-content> group compared with control group. Compared with non\u2010EDS<\/jats:styled-content> patients, patients with EDS<\/jats:styled-content> showed significantly higher metabolic score (3.22\u2009\u00b1\u20090.94 vs 1.96\u2009\u00b1\u20091.06). After adjustment for confounders, ESS<\/jats:styled-content> score, log insulin and age significantly predicted the metabolic score (\u03b2\u2009=\u20090.567, P<\/jats:italic>\u2009=\u20090.000; \u03b2\u2009=\u20090.197, P<\/jats:italic>\u2009=\u20090.001 and \u03b2\u2009=\u20090.118, P<\/jats:italic>\u2009=\u20090.048, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>EDS<\/jats:styled-content> was independently correlated with the sum of metabolic components in severe OSA<\/jats:styled-content> patients. Our study suggested that EDS<\/jats:styled-content> might be a potentially useful clinical marker to identify patients with severe OSA<\/jats:styled-content> at risk of MetS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12276","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T06:27:55Z","timestamp":1422426475000},"page":"714-721","source":"Crossref","is-referenced-by-count":27,"title":["The relationship between excessive daytime sleepiness and metabolic syndrome in severe obstructive sleep apnea syndrome"],"prefix":"10.1111","volume":"10","author":[{"given":"Jie\u2010feng","family":"Huang","sequence":"first","affiliation":[{"name":"Fujian Provincial Sleep\u2010disordered Breathing Clinic Center Laboratory of Respiratory Disease of the Fujian Medical University Department of Respiratory Medicine First Affiliated Hospital of Fujian Medical University Fuzhou Fujian 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Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Hua","family":"Yu","sequence":"additional","affiliation":[{"name":"Fujian Provincial Sleep\u2010disordered Breathing Clinic Center Laboratory of Respiratory Disease of the Fujian Medical University Department of Respiratory Medicine First Affiliated Hospital of Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Chai","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Sleep\u2010disordered Breathing Clinic Center Laboratory of Respiratory Disease of the Fujian Medical University Department of Respiratory Medicine First Affiliated Hospital of Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Fujian Provincial Sleep\u2010disordered 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