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A meta\u2010analysis was performed to determine the efficacy and safety of long\u2010term inhaled antibiotics for patients with non\u2010CF<\/jats:styled-content> bronchiectasis.<\/jats:p><\/jats:sec>Methods<\/jats:title>P<\/jats:styled-content>ubM<\/jats:styled-content>ed, E<\/jats:styled-content>mbase, W<\/jats:styled-content>eb of Science and C<\/jats:styled-content>ochrane L<\/jats:styled-content>ibrary databases were searched up to M<\/jats:styled-content>arch 20, 2014. Reduction of sputum bacterial density, eradication of sputum Pseudomonas aeruginosa<\/jats:italic>, the risk of exacerbations and other clinical outcomes related to inhalation treatment were analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>Three hundred seventy articles were searched. Eight randomized controlled trials recruiting 539 patients were included in this meta\u2010analysis. Long\u2010term inhaled antibiotics showed an obvious reduction of the sputum bacterial density [weighted mean difference\u2009=\u20092.85, 95% confidence interval (CI<\/jats:styled-content>): 1.6\u20134.09, P<\/jats:italic>\u2009<\u20090.00001] and augment eradication of sputum P<\/jats:italic><\/jats:styled-content>.\u2009aeruginosa<\/jats:italic> [odds ratio (OR<\/jats:styled-content>)\u2009=\u20096.6, 95% CI<\/jats:styled-content>: 2.93\u201314.86, P<\/jats:italic>\u2009<\u20090.00001]. No evidences showed higher risk of P<\/jats:italic><\/jats:styled-content>.\u2009aeruginosa<\/jats:italic> resistance after inhaled therapy. In addition, nebulized therapy reduced the amount of patients with exacerbation (OR<\/jats:styled-content>\u2009=\u20090.46, 95% CI<\/jats:styled-content>: 0.21\u20131.00, P<\/jats:italic>\u2009=\u20090.05). However, patients with inhaled antibiotics were more likely to suffer wheeze (OR<\/jats:styled-content>\u2009=\u20096.74, 95% CI<\/jats:styled-content>: 2.22\u201320.52, P<\/jats:italic>\u2009=\u20090.0008) and bronchospasm (OR<\/jats:styled-content>\u2009=\u20092.84, 95% CI<\/jats:styled-content>: 1.11\u20137.25, P<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>For patients with non\u2010CF<\/jats:styled-content> bronchiectasis, long\u2010term inhaled antibiotics can effectively reduce the sputum bacterial density, increase P.A<\/jats:styled-content> eradication and attenuate the risk of exacerbation, however, accompanied with higher risk of wheeze and bronchospasm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12278","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T09:20:22Z","timestamp":1422264022000},"page":"731-739","source":"Crossref","is-referenced-by-count":48,"title":["Efficacy and safety of long\u2010term inhaled antibiotic for patients with noncystic fibrosis bronchiectasis: a meta\u2010analysis"],"prefix":"10.1111","volume":"10","author":[{"given":"Jia\u2010Wei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai China"},{"name":"Department of Respiratory Medicine Shanghai pulmonary Hospital Soochow University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Chao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Wen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 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