{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T16:13:05Z","timestamp":1717949585330},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Abstract<\/jats:title>Background and Aims<\/jats:title>The precise mechanism of pathogenesis in exudation of effusions is uncertain. Released factors in inflammation and malignancy of pleura are related to incremented permeability of the micro\u2010pleural vessels. A<\/jats:styled-content>ngiopoietins (A<\/jats:styled-content>ng) take part in development of angiogenesis and pleural inflammation. I<\/jats:styled-content>nterleukin\u20108 (IL<\/jats:styled-content>\u20108) influences proliferation and tumor angiogenesis and it is expressed in cancer. The aims of this study were to investigate the relationship between inflammation, angiogenesis and etiologies of exudative effusions, and to evaluate the diagnostic value in differentiating malignant from benign.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study includes 49 pleural fluid (PF<\/jats:styled-content>) samples. A<\/jats:styled-content>ng\u20102 and IL<\/jats:styled-content>\u20108 in PF<\/jats:styled-content> and serum were estimated.<\/jats:p><\/jats:sec>Results<\/jats:title>Ten patients were transudative and 39 patients were exudative fluid, subdivided into 16 benign and 23 malignant effusion. A<\/jats:styled-content>ng\u20102 and IL<\/jats:styled-content>\u20108 either fluid level or ratio were in significantly high in exudative more than in transudative fluid (P<\/jats:italic>\u2009=\u20090.002). A<\/jats:styled-content>ng\u20102 and IL<\/jats:styled-content>\u20108 in PF<\/jats:styled-content> were in high level than in serum of exudative and transudative. A<\/jats:styled-content>ng\u20102 fluid level and ratio were significantly high in benign exudative effusion (P<\/jats:italic>\u2009=\u20090.01, P<\/jats:italic>\u2009=\u20090.05, respectively), while IL<\/jats:styled-content>\u20108 level was significantly high in malignant exudative effusion (P<\/jats:italic>\u2009=\u20090.04). Cut\u2010off points for PF A<\/jats:styled-content>ng\u20102 and IL<\/jats:styled-content>\u20108 in differentiating malignant from benign exudative were 15.67\u2009ng\/mL, 325.54\u2009pg\/mL, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our results support the evidence that angiogenesis and inflammatory pathways are linked, and that inflammation and vascular permeability of pleura constitutes the pathogenic basis of the majority of exudative effusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12302","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T21:45:21Z","timestamp":1428011121000},"page":"49-57","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic value of pro\u2010inflammatory cytokine and pro\u2010angiogenesis factor in differentiating malignant from benign exudative effusion"],"prefix":"10.1111","volume":"11","author":[{"given":"Radwa Ahmed","family":"Elhefny","sequence":"first","affiliation":[{"name":"Department of Chest Diseases Fayoum University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa Moawad","family":"Shaban","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olfat Gamil","family":"Shaker","sequence":"additional","affiliation":[{"name":"Department of Chemical Biochemistry and Molecular Biology Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp010731"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"ii8","DOI":"10.1136\/thx.58.suppl_2.ii8","article-title":"BTS guidelines for the investigation of unilateral pleural effusion in 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