{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:34:23Z","timestamp":1785180863288,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Abstract<\/jats:title>Background and Aims<\/jats:title>Endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS<\/jats:styled-content>\u2010TBNA<\/jats:styled-content>) is an accurate and minimally invasive technique that has been shown to have excellent diagnostic yield in the diagnosis of mediastinal and hilar lymphadenopathy. However, endoscopic bronchial biopsy (EBB<\/jats:styled-content>) and transbronchial lung biopsy (TBLB<\/jats:styled-content>) are still the standard method for making a pathologic diagnosis of sarcoidosis. The aim of this study was to compare the diagnostic yield of EBUS<\/jats:styled-content>\u2010TBNA<\/jats:styled-content> and TBLB<\/jats:styled-content> through a flexible bronchoscope in patients with stage I<\/jats:styled-content> and II<\/jats:styled-content> sarcoidosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 653 patients with suspected stage I<\/jats:styled-content> and II<\/jats:styled-content> sarcoidosis were included in this retrospective study. After radiological assessment, patients were qualified to bronchoscopy. Patients underwent sequential EBUS<\/jats:styled-content>\u2010TBNA<\/jats:styled-content> followed by TBLB<\/jats:styled-content> and\/or EBB<\/jats:styled-content>. In all patients, 1056 biopsies from mediastinal lymph nodes group were taken.<\/jats:p><\/jats:sec>Results<\/jats:title>In all of the biopsied lymph nodes, positive results were obtained in 549 patients (84%). In 180 patients with stage II TBLB<\/jats:styled-content>, a biopsy was taken from affected part of the lung. Positive results were found in 79 patients (43.9%). EBB<\/jats:styled-content> was performed in 340 patients, with a positive result in 101 (29.7%). Mediastinoscopy was performed in 60 patients (9.2%) with a negative result in EBUS<\/jats:styled-content>\u2010TBNA<\/jats:styled-content>, TBLB<\/jats:styled-content> and\/or EBB<\/jats:styled-content>. Non\u2010caseating granulomas were found in 48 patients. The sensitivity of TBLB<\/jats:styled-content> technique alone was significantly lower at 43.9% (79\/180) (P<\/jats:italic>\u2009<\u20090.001). The sensitivity of EBB<\/jats:styled-content> was significantly lower than EBUS<\/jats:styled-content>\u2010TBNA<\/jats:styled-content> and TBLB<\/jats:styled-content> and reached 29.7% (101\/340) (P<\/jats:italic>\u2009<\u20090.0001, P<\/jats:italic>\u2009<\u20090.003). The overall diagnostic accuracy for EBUS<\/jats:styled-content>\u2010TBNA<\/jats:styled-content> was 84%, and the combination of EBUS<\/jats:styled-content>\u2010TBNA<\/jats:styled-content> with standard bronchoscopic techniques had a diagnostic accuracy of 89%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The diagnostic yield of the EBUS<\/jats:styled-content>\u2010TBNA<\/jats:styled-content> for stage I<\/jats:styled-content> and II<\/jats:styled-content> sarcoidosis is clearly higher than for TBLB<\/jats:styled-content> and EBB<\/jats:styled-content>. The combination of EBUS<\/jats:styled-content>\u2010TBNA<\/jats:styled-content> with standard bronchoscopic techniques is safe and feasible, and optimizes the diagnostic yield in patients with pulmonary sarcoidosis and enlarged intrathoracic lymph nodes. EBUS<\/jats:styled-content>\u2010TBNA<\/jats:styled-content> in combination with standard bronchoscopy may be considered to be the first\u2010line investigation in patients with suspected sarcoidosis and enlarged intrathoracic lymphadenopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12304","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T09:10:30Z","timestamp":1430125830000},"page":"58-63","source":"Crossref","is-referenced-by-count":49,"title":["The role of EBUS<\/scp>\u2010TBNA<\/scp> and standard bronchoscopic modalities in the diagnosis of sarcoidosis"],"prefix":"10.1111","volume":"11","author":[{"given":"Dariusz Adam","family":"Dziedzic","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery National Research Institute of Chest Disease Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Peryt","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Research Institute of Chest Disease Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeusz","family":"Orlowski","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Research Institute of Chest Disease Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.51.3.238"},{"key":"e_1_2_5_3_1","first-page":"105","article-title":"Pulmonary sarcoidosis","volume":"32","author":"Lynch JP","year":"2005","journal-title":"Eur Respir 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