{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:24:15Z","timestamp":1740147855910,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T00:00:00Z","timestamp":1433980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270078","81470211"],"award-info":[{"award-number":["81270078","81470211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Granulomatous inflammation is considered an immune mechanism against infection or certain non\u2010neoplastic conditions. Sarcoidosis\u2010like granuloma reactions (<jats:styled-content style=\"fixed-case\">SGRs<\/jats:styled-content>) in primary tumors or in regional lymph nodes are occasionally observed; however, they are rare in lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case review<\/jats:title><jats:p>In this study, we reported on a case of squamous lung cancer with swollen mediastinal lymph nodes, similar to sarcoidosis. He was misdiagnosed as benign lymph node <jats:styled-content style=\"fixed-case\">SGRs<\/jats:styled-content> or tuberculosis for 2\u2009years. Reexamination of the lymph node by immunohistochemistry confirmed the malignant disease. The lung cancer appeared to remain in the stasis phase for 2 years and then burst to stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> with the amplification of the fibroblast growth factor receptor 1 gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although tumor\u2010induced draining lymph node granulomatous reactions are rare, they did exist in some of the patients. In this case, differential diagnoses with malignant granulomas should be performed carefully to avoid the misdiagnosis of a benign disease. The biological significance of such a granulomatous response in inducing tumor remission or in shielding tumor cells from host lymphocytes remains obscure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12306","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T09:10:52Z","timestamp":1430125852000},"page":"530-534","source":"Crossref","is-referenced-by-count":1,"title":["A sarcoidosis\u2010like granuloma reaction in the lymph nodes of a patient with lung squamous cancer: from stasis to the invasive phase with <scp>FGFR<\/scp>1 gene amplification"],"prefix":"10.1111","volume":"10","author":[{"given":"Hailong","family":"Wei","sequence":"first","affiliation":[{"name":"Respiratory Division of Zhongshan Hospital Shanghai Institute of Respiratory Disease Fudan University  Shanghai China"},{"name":"Respiratory Division People's Hospital of Leshan City  Leshan Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hou","sequence":"additional","affiliation":[{"name":"Pathology Division of Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue","family":"Pan","sequence":"additional","affiliation":[{"name":"Respiratory Division of Zhongshan Hospital Shanghai Institute of Respiratory Disease Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiong","family":"Su","sequence":"additional","affiliation":[{"name":"Respiratory Division of Zhongshan Hospital Shanghai Institute of Respiratory Disease Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqiong","family":"Li","sequence":"additional","affiliation":[{"name":"Respiratory Division People's Hospital of Leshan City  Leshan Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Respiratory Division of Zhongshan Hospital Shanghai Institute of Respiratory Disease Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Chen","sequence":"additional","affiliation":[{"name":"Respiratory Division of Zhongshan Hospital Shanghai Institute of Respiratory Disease Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100240010113"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcp.0000134400.88832.9c"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyl141"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2009.03.005"},{"key":"e_1_2_5_6_1","first-page":"252","volume-title":"Lymph Node Pathology","author":"Ioachim HL","year":"1995"},{"key":"e_1_2_5_7_1","first-page":"13","article-title":"Granulomatous inflammation in lymph nodes draining cancer: a coincidence or a significant association","volume":"1","author":"Bhatia A","year":"2009","journal-title":"Int J Med Med Sci"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.59446"},{"key":"e_1_2_5_9_1","first-page":"177","article-title":"Sarcoid reactions in primary pulmonary carcinoma: report of seven cases","volume":"5","author":"Kamiyoshihara M","year":"1998","journal-title":"Oncol Rep"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.640"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.229"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.8622"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2943"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.4029"},{"key":"e_1_2_5_15_1","first-page":"13","article-title":"Granulomatous inflammation in lymph nodes draining cancer: a coincide or a significant association","volume":"1","author":"Bhatia A","year":"2009","journal-title":"Int J Med Med Sci"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:42:31Z","timestamp":1696304551000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,11]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/crj.12306"],"URL":"https:\/\/doi.org\/10.1111\/crj.12306","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"type":"print","value":"1752-6981"},{"type":"electronic","value":"1752-699X"}],"subject":[],"published":{"date-parts":[[2015,6,11]]}}}