{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T07:06:53Z","timestamp":1720940813113},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of a 41\u2010year\u2010old man presenting with persisting fevers over 2 weeks. The patient had spent 4 weeks in Central America. He was in control of a stable stage II sarcoidosis. Laboratory and various microbiological tests as well as chest radiography led to no diagnosis. Activated sarcoidosis was hypothesized as the most likely diagnosis. However, we considered an infectious process as a differential diagnosis, in detail, the travel history imposed histoplasmosis. Chest\u2010CT documented localized interstitial consolidations. Bronchoscopy with bronchoalveolar lavage (BAL) and biopsy was performed. Results of BAL fluid, biopsy, distinct sarcoidosis serum markers and a borderline positive histoplasmosis\u2010serology yielded in a diagnostic dilemma as no distinct diagnosis was drawable. After the patient was already started on a prednisolone trial, the final diagnosis \u2013 pulmonary histoplasmosis \u2013 could be achieved via positive culture and PCR out of the BAL fluid. This case shows the difficult differentiation between an acute exacerbation of a chronic pulmonary disease and a concomitant infection, which was especially aggravated in this case as the histoplasmosis masqueraded an acute picture of sarcoidosis.<\/jats:p>","DOI":"10.1111\/crj.12344","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T23:21:31Z","timestamp":1436224891000},"page":"374-377","source":"Crossref","is-referenced-by-count":6,"title":["A diagnostic predicament: activated sarcoidosis or pulmonary histoplasmosis. A case report"],"prefix":"10.1111","volume":"11","author":[{"given":"Tilman","family":"Lingscheid","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Respiratory Medicine Charit\u00e9 Universit\u00e4tsmedizin Berlin Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"von Heinz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Respiratory Medicine Charit\u00e9 Universit\u00e4tsmedizin Berlin Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Klages","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Respiratory Medicine Charit\u00e9 Universit\u00e4tsmedizin Berlin Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Rickerts","sequence":"additional","affiliation":[{"name":"FG16 Mycotic and Parasitic Agents and Mycobacteria, Robert Koch Institute, Nordufer 20, 13353 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Tintelnot","sequence":"additional","affiliation":[{"name":"FG16 Mycotic and Parasitic Agents and Mycobacteria, Robert Koch Institute, Nordufer 20, 13353 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Gerhold","sequence":"additional","affiliation":[{"name":"Department of Pathology Charit\u00e9 Universit\u00e4tsmedizin Berlin Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg\u2010Wilhelm","family":"Oestmann","sequence":"additional","affiliation":[{"name":"Department of Radiology Charit\u00e9 Universit\u00e4tsmedizin Berlin Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Respiratory Medicine Charit\u00e9 Universit\u00e4tsmedizin Berlin Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Temmesfeld\u2010Wollbr\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Respiratory Medicine Charit\u00e9 Universit\u00e4tsmedizin Berlin Charit\u00e9platz 1 10117 Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Suttorp","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Respiratory Medicine Charit\u00e9 Universit\u00e4tsmedizin Berlin Charit\u00e9platz 1 10117 Berlin 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