{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:50:09Z","timestamp":1784346609946,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271840\/H1904 and 81030032\/H19"],"award-info":[{"award-number":["81271840\/H1904 and 81030032\/H19"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Community\u2010acquired pneumonia (CAP) severity scores perform well in predicting mortality of CAP patients, but their applicability in influenza pneumonia is powerless.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of our research was to test the efficiency of PO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> and CAP severity scores in predicting mortality and intensive care unit (ICU) admission with influenza pneumonia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed all patients with positive influenza virus RNA detection in Beijing Chao\u2010Yang Hospital during the 2009\u20132014 influenza seasons. Outpatients, inpatients with no pneumonia and incomplete data were excluded. We used receiver operating characteristic curves (ROCs) to verify the accuracy of severity scores or indices as mortality predictors in the study patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 170 hospitalized patients with influenza pneumonia, 30 (17.6%) died. Among those who were classified as low\u2010risk (predicted mortality 0.1%\u20132.1%) by pneumonia severity index (PSI) or confusion, urea, respiratory rate, blood pressure, age \u226565 year (CURB\u201065), the actual mortality ranged from 5.9 to 22.1%. Multivariate logistic regression indicated that hypoxia (PO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>\u2009\u2264\u2009250) and lymphopenia (peripheral blood lymphocyte count &lt;0.8 \u00d7 10<jats:sup>9<\/jats:sup>\/L) were independent risk factors for mortality, with OR value of 22.483 (95% confidence interval 4.927\u2013102.598) and 5.853 (95% confidence interval 1.887\u201318.152), respectively. PO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> combined lymphocyte count performed well for mortality prediction with area under the curve (AUC) of 0.945, which was significantly better than current CAP severity scores of PSI, CURB\u201065 and confusion, respiratory rate, blood pressure, age \u226565 years for mortality prediction (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The scores or indices for ICU admission prediction to hospitalized patients with influenza pneumonia confirmed a similar pattern and PO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> combined lymphocyte count was also the best predictor for predicting ICU admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, we found that PO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> combined lymphocyte count is simple and reliable predictor of hospitalized patients with influenza pneumonia in predicting mortality and ICU admission. When PO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>\u2009\u2264\u2009250 or peripheral blood lymphocyte count &lt;0.8 \u00d7 10<jats:sup>9<\/jats:sup>\/L, the clinician should pay great attention to the possibility of severe influenza pneumonia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12346","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T23:14:57Z","timestamp":1436224497000},"page":"352-360","source":"Crossref","is-referenced-by-count":62,"title":["Mortality prediction to hospitalized patients with influenza pneumonia: PO<sub>2<\/sub>\/FiO<sub>2<\/sub> combined lymphocyte count is the answer"],"prefix":"10.1111","volume":"11","author":[{"given":"Shu Jing","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu Xin","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University  Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,11]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization (WHO)Weekly Epidemiological Record. 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