{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:47:13Z","timestamp":1695620833099},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adenosine monophosphate (AMP) may reflect airway inflammation and hyperresponsiveness, but relationship between AMP and histamine (His, a conventional stimulus) bronchial provocation test (BPT) in asthma is not fully elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare both BPTs and determine their utility in reflecting changes of asthmatic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>BPTs were performed in a cross\u2010over fashion, at 2\u20134 day intervals. Cumulative doses eliciting 20% FEV<jats:sub>1<\/jats:sub>fall (PD<jats:sub>20<\/jats:sub>FEV<jats:sub>1<\/jats:sub>), diagnostic performance and adverse events (AEs) were compared. Patients with PD<jats:sub>20<\/jats:sub>FEV<jats:sub>1<\/jats:sub> lower than geometric mean were defined as responders, otherwise poor responders. Patients with uncontrolled and partly controlled asthma, who maintained their original inhaled corticosteroids therapy, underwent reassessment of airway responsiveness and asthmatic symptoms 3 and 6 months after.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen uncontrolled, 22 partly controlled and 19 controlled asthmatic patients and 24 healthy subjects were recruited. Lower PD<jats:sub>20<\/jats:sub>FEV<jats:sub>1<\/jats:sub> geometric means were associated with poorer asthma control in His\u2010BPT (0.424 \u03bcmol vs 1.684 \u03bcmol vs 3.757 \u03bcmol), but not AMP\u2010BPT (11.810 \u03bcmol vs 7.781 \u03bcmol vs 10.220 \u03bcmol). Both BPTs yielded similar overall diagnostic performance in asthma (area under curve: 0.842 in AMP\u2010BPT vs 0.850 in His\u2010BPT). AEs, including wheezing and tachypnea, were similar and mild. Ten patients with uncontrolled and 10 partly controlled asthma were followed\u2010up. At months 3 and 6, we documented an increase in PD<jats:sub>20<\/jats:sub>FEV<jats:sub>1<\/jats:sub>\u2010AMP and PD<jats:sub>20<\/jats:sub>FEV<jats:sub>1<\/jats:sub>\u2010His, which did not correlate with reduction asthmatic symptom scores. This overall applied in responders and poor responders of AMP\u2010BPT and His\u2010BPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite higher screening capacity of well\u2010controlled asthma, AMP\u2010BPT confers similar diagnostic performance and safety with His\u2010BPT. AMP\u2010BPT might not preferentially reflect changes asthmatic symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12360","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T09:05:23Z","timestamp":1439197523000},"page":"470-480","source":"Crossref","is-referenced-by-count":0,"title":["Adenosine monophosphate is not superior to histamine for bronchial provocation test for assessment of asthma control and symptoms"],"prefix":"10.1111","volume":"11","author":[{"given":"Fan","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China"},{"name":"Affiliated Liwan Hospital of Guangzhou Medical University Guangzhou, Guangdong, 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