{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T03:58:42Z","timestamp":1770782322997,"version":"3.50.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Cognitive impairment is common among patients with obstructive sleep apnea syndrome (OSAS). In this study, we aimed to investigate the effect of continuous positive airway pressure (CPAP) therapy on serum insulin\u2010like growth factor\u20101 (IGF\u20101) levels and cognitive functions in patients with OSAS.<\/jats:p><jats:p><jats:italic>Patient\/Methods<\/jats:italic>: Thirty\u2010three patients with newly diagnosed OSAS and 17 healthy\u2010control subjects enrolled in the study. All individuals completed the mini\u2010mental state examination (MMSE) to evaluate cognitive function. Blood samples were taken at the end of the polysomnography in the morning and the same procedures were repeated 3 months after starting CPAP treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the OSAS group, the baseline MMSE score was 23.5\u2009\u00b1\u20093.6, and serum IGF\u20101 level was 79.1\u2009\u00b1\u200936.1 ng\/mL. Both values were significantly lower compared with the control group (mean MMSE score\u2009=\u200928.1\u2009\u00b1\u20091.4, <jats:italic>P<\/jats:italic>\u2009=\u20090.0001; mean serum IGF\u20101 level\u2009=\u2009147.1\u2009\u00b1\u200949.1 ng\/mL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Three months after CPAP treatment, OSAS patients showed a significant improvement in MMSE scores (26.5\u2009\u00b1\u20092.8, <jats:italic>P<\/jats:italic>\u2009=\u20090.0001) and serum IGF\u20101 level (129.1\u2009\u00b1\u200958.2, <jats:italic>P<\/jats:italic>\u2009=\u20090.0001). In contrast, baseline and third\u2010month measurements for IGF\u20101 levels and MMSE scores were not significantly different in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results indicate that effective CPAP therapy in OSAS patients leads to significant improvement in cognitive functions and IGF\u20101 even in a short\u2010term follow\u2010up. Cognitive function assessment might be a part of evaluation in OSAS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12365","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T23:51:10Z","timestamp":1439250670000},"page":"506-513","source":"Crossref","is-referenced-by-count":20,"title":["The effect of <scp>CPAP<\/scp> therapy on insulin\u2010like growth factor and cognitive functions in obstructive sleep apnea patients"],"prefix":"10.1111","volume":"11","author":[{"given":"Asiye","family":"Kanbay","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Istanbul Medeniyet University School of Medicine Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan Cerrah","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuri","family":"Tutar","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"K\u00f6stek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Istanbul Medeniyet University School of Medicine Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuhal","family":"\u00d6zer \u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Buyukoglan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Erciyes University School of Medicine Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liborio","family":"Parrino","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Sleep Disorders Center, University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.6.683"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704105134"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2008.00660.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2002.00308.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.065"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2004.01.001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2008.00705.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.3.303"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2002.00289.x"},{"key":"e_1_2_5_11_1","first-page":"1388","article-title":"[Insulin\u2010like growth factor\u2010I and cognitive function in patients with obstructive sleep apnea syndrome]","volume":"82","author":"Xu Y","year":"2002","journal-title":"Zhonghua yi xue za zhi"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0010"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.02.047"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3580"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790060110016"},{"key":"e_1_2_5_16_1","unstructured":"RechtschaffenA AnthonyK.A Manual of Standardized Terminology Techniques and Scoring System for Sleep Stages of Human Subjects. 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