{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:13:42Z","timestamp":1695622422005},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>We report the first known case of malignant pleural effusion (MPE) as the sole presenting feature of clinically occult primary fallopian tube carcinoma (PFTC). A 57\u2010year\u2010old healthy woman was admitted with dyspnea. Evaluation demonstrated a right pleural effusion, fluid of which was malignant. The immunohistochemical profile, including negative calretinin, favored metastatic adenocarcinoma over mesothelioma but could not identify the primary tumour site. Pleural biopsy was not pursued as it would not have helped localize the primary. Chest, abdomen and pelvic computed tomography (CT) demonstrated only borderline lymphadenopathy in the left para\u2010aortic lymph node chain that was hypermetabolic on positron emission tomography. Ultrasound and CT showed normal adnexal anatomy. These findings, coupled with an elevated serum CA\u2010125, prompted empiric neoadjuvant chemotherapy targeting epithelial ovarian carcinoma (EOC) followed by surgery, which revealed a tiny left PFTC with negative peritoneal washings. Sampled left para\u2010aortic lymph nodes were positive. The pleural effusion resolved after chemotherapy. Malignant pleural disease without peritoneal involvement is more characteristic of PFTC than of EOC, in which MPE is common but almost always accompanies peritoneal carcinomatosis. The extensive lymphatic supply of the fallopian tube promotes distant metastasis of small, seemingly localized tumours. This case is a reminder that the clinician should not be dissuaded from considering carcinoma of M\u00fcllerian origin, especially PFTC, as the cause of a MPE even in the face of normal gynecologic imaging. Appropriately broad immunohistochemical staining and careful attention to even minimal lymphadenopathy can be invaluable in pinpointing the primary tumour site in such patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12423","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T07:11:32Z","timestamp":1449645092000},"page":"1086-1090","source":"Crossref","is-referenced-by-count":2,"title":["Clinically occult primary fallopian tube carcinoma presenting as a malignant pleural effusion"],"prefix":"10.1111","volume":"11","author":[{"given":"Robert","family":"Hiensch","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Icahn School of Medicine at Mount Sinai New York NY 10029 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Meinhof","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Icahn School of Medicine at Mount Sinai New York NY 10029 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anatoly","family":"Leytin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Elmhurst Hospital Center Icahn School of Medicine at Mount Sinai Queens NY 11373 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Hagopian","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Elmhurst Hospital Center Icahn School of Medicine at Mount Sinai Queens NY 11373 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Szemraj","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Elmhurst Hospital Center Icahn School of Medicine at Mount Sinai Queens NY 11373 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Epelbaum","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Elmhurst Hospital Center Icahn School of Medicine at Mount Sinai Queens NY 11373 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.03.023"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001115)89:10<2076::AID-CNCR7>3.0.CO;2-V"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2012.10.001"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00586-5"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.06.025"},{"issue":"6","key":"e_1_2_4_7_1","first-page":"654","article-title":"Adenocarcinoma of the fallopian tube. 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