{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:58:20Z","timestamp":1768553900585,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T00:00:00Z","timestamp":1452038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Oxidative stress (OS) plays a crucial role in the pathogenesis of inflammatory lung diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>(i) We determined whether acute bronchiolitis (AB) caused by respiratory syncytial virus (RSV) induced OS; (ii) assessed whether OS biomarkers correlated with the severity of RSV\u2010AB; and (iii) studied whether the levels of interleukins are associated with OS biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an observational study by comparing healthy infants (Group 1) with RSV\u2010AB infants, classified as Group 2 (pulse oximetry (SpO<jats:sub>2<\/jats:sub>) &gt;93%), and Group 3 (SpO<jats:sub>2<\/jats:sub>\u2009\u2264\u200992%), which needed oxygen therapy. Blood samples were collected to determine the levels of lipid peroxidation (LPO) products (LPO), total glutathione (TG), oxidised glutathione (GSSG), reduced glutathione (GSH), glutathione peroxidase (GPx), interleukins (ILs) IL\u201010, IL\u20106, IL\u20108, interferon\u2010gamma (IFN\u03b3), tumour necrosis factor\u2010alpha (TNF\u03b1) and macrophage inflammatory proteins (MIP \u03b1 and MIP \u03b2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six RSV\u2010AB infants (47% needed oxygen therapy) and 27 healthy infants were included. The GSH\/GSSG ratio was lower in RSV\u2010AB infants than in Group 1 (<jats:italic>P<\/jats:italic>&lt;0.001). GSSG and GPx were significantly higher in Group 3. GSSG predicted the need for oxygen therapy with an optimal cut\u2010off point of 15 \u00b5M\/g for haemoglobin. The GSH\/GSSG ratio negatively correlated with IL\u20106 (<jats:italic>P<\/jats:italic>: 0.014), IL\u20108 <jats:italic>(P<\/jats:italic>: 0.014) and IL\u201010 (<jats:italic>P<\/jats:italic>: 0.033). Group 3 exhibited a direct correlation between GPx and IL\u201010 levels (<jats:italic>P<\/jats:italic>: 0.024) and between LPO and MIP \u03b2 (<jats:italic>P<\/jats:italic>: 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RSV induced OS in AB. An increase in GSSG correlated with the disease severity in the infants. OS may contribute to the pathogenesis of RSV\u2010AB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12425","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T05:45:06Z","timestamp":1449726306000},"page":"839-846","source":"Crossref","is-referenced-by-count":30,"title":["Oxidative stress and inflamatory plasma biomarkers in respiratory syncytial virus bronchiolitis"],"prefix":"10.1111","volume":"11","author":[{"given":"Gloria","family":"Moreno\u2010Sol\u00eds","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Paediatric Pulmonology and Allergy Unit Reina Sofia University Hospital Cordoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"dela Torre\u2010Aguilar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), University of Cordoba  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