{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:07:32Z","timestamp":1774382852727,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81000951"],"award-info":[{"award-number":["81000951"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["68475"],"award-info":[{"award-number":["68475"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangzhou medical college, Dr. Startup funds","award":["2008C37"],"award-info":[{"award-number":["2008C37"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the value of tumor biomarkers in the determination of tumor\u2010related pleural effusion (PE). Cytological examination of the pleural fluid has a limited sensitivity in diagnosing tumor PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pleural fluid and serum samples were obtained from 1137 patients and PE etiology was determined by multiple diagnostic techniques. Carcinoembryonic antigen (CEA) levels were measured in both pleural fluid and serum samples. Levels of cancer antigen (CA) 125, glucose, and lactate dehydrogenase (LDH) were assessed in pleural fluid specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>601 PE patients were diagnosed with tumors, while 595 tested individuals were tumor\u2010free. Among the measured biomarkers, pleural fluid CA 125, glucose, and LDH levels, and serum CEA amounts were comparable between tumor and tumor\u2010free PE patients (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Only pleural fluid CEA levels were significantly different between the two groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). A CEA cutoff of 2.645 ng\/mL yielded sensitivity and specificity of 69.4% and 82.2%, respectively, for tumor\u2010related PE detection. The area under the curve for CEA was 0.740 (95%CI: 0.710\u20130.770).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CEA levels in pleural fluid were a potential biomarker for the detection of tumor\u2010related PE. These findings provide an easy and simple method for clinical screening and detection of PE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12431","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T11:55:00Z","timestamp":1449748500000},"page":"881-886","source":"Crossref","is-referenced-by-count":11,"title":["Pleural fluid carcinoembryonic antigen as a biomarker for the discrimination of tumor\u2010related pleural effusion"],"prefix":"10.1111","volume":"11","author":[{"given":"Huiling","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory Hainan Branch of PLA Hospital Sanya 572000 Hainan Province China"},{"name":"Department of Cardiothoracic Surgery Guangzhou Institute of Respiratory Disease, State Key Laboratary of Respiratory Disease, The First Hospital Affiliated to Guangzhou Medical University Guangzhou 510120 Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Guangzhou Institute of Respiratory Disease, State Key Laboratary of Respiratory Disease, The First Hospital Affiliated to Guangzhou Medical University Guangzhou 510120 Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Guangzhou Institute of Respiratory Disease, State Key Laboratary of Respiratory Disease, The First Hospital Affiliated to Guangzhou Medical University Guangzhou 510120 Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanshan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Guangzhou Institute of Respiratory Disease, State Key Laboratary of Respiratory Disease, The First Hospital Affiliated to Guangzhou Medical University Guangzhou 510120 Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Guangzhou Institute of Respiratory Disease, State Key Laboratary of Respiratory Disease, The First Hospital Affiliated to Guangzhou Medical University Guangzhou 510120 Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Textbook of Respiratory Medicine","author":"Broaddus C","year":"2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2005.12.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12019-007-8016-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2012.11.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.1.73"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.6.1757"},{"key":"e_1_2_7_8_1","volume-title":"Pleural Abnormalities and Pleural Effusion Chapters in Fraser and Par's Diagnosis of Diseases of the Chest","author":"Fraser RS","year":"1999"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2010.01794.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2008.01291.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.077958"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.3.978"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0011-5029(92)90007-C"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.58.suppl_2.ii8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991015)86:8<1488::AID-CNCR15>3.0.CO;2-Y"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(03)00120-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.1.363"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12195"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12091"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-1220-2"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12431","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:50:24Z","timestamp":1695563424000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,25]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/crj.12431"],"URL":"https:\/\/doi.org\/10.1111\/crj.12431","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,25]]}}}