{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:10:19Z","timestamp":1776705019594,"version":"3.51.2"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epstein\u2013Barr virus (EBV) infection may induce immune suppression in several ways, which may influence the proper host response to other pathogens and lead to a bad outcome of critically ill patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center, retrospective, observational study. All patients admitted to an ICU because of respiratory failure were included. EBV detection from lower respiratory tract (LRT) and serum samples were routinely performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight consecutive cases who were admitted to the ICU at high\u2010risk for an infection or clinical signs of an infection were included in our study. Among the 28 patients, 15 were LRT\u2010positive for EBV (53.6%), and 8 were seropositive for EBV (28.6%). Among the LRT EBV\u2010positive patients, pneumonia was the main indication for ICU admission (93.3%), and in LRT EBV\u2010negative patients, acute exacerbation of COPD (AECOPD) was another indication for ICU admission (46.2%). The CD3+ T cell count (especially the CD3+CD8+ T cell count) was lower than the normal range in LRT\u2010 and serum EBV\u2010positive patients; these count were in the normal range in EBV\u2010negative patients. The ICU mortality was 32.1% for all patients. The mortality rate was significantly higher in patients who were seropositive for EBV than seronegative patients (62.5% vs 20.0%). No differences were shown between any outcome parameters for LRT EBV\u2010positive and \u2010negative patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that EBV DNA is detected in LRT and serum samples of a significant number of ICU patients with respiratory failure, and seropositivity for EBV was associated with mortality. This finding maybe correlated with a low CD3+CD8+ T cell count.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12433","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T11:54:41Z","timestamp":1449748481000},"page":"895-900","source":"Crossref","is-referenced-by-count":16,"title":["Positive Epstein\u2013Barr virus detection and mortality in respiratory failure patients admitted to the intensive care unit"],"prefix":"10.1111","volume":"11","author":[{"given":"Hangyong","family":"He","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing 10020 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of No.1 Internal Medicine the Shihua Hospital of Luoyang Luoyang Henan Province 471012 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Heilongjiang Province Hospital Harbin Heilongjiang Province 150036 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing 10020 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a3aa43"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200609-1322OC"},{"key":"e_1_2_6_4_1","first-page":"707","article-title":"Epstein\u2010Barr virus in healthy individuals from Portugal","volume":"24","author":"Sousa H","year":"2011","journal-title":"Acta Med Port."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-013-0306-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181890415"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/2319-4170.132905"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.6.2633-2640.2003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.22013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.12.7481"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002328"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12433","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:50:29Z","timestamp":1695563429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,4]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/crj.12433"],"URL":"https:\/\/doi.org\/10.1111\/crj.12433","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,4]]}}}