{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:35:34Z","timestamp":1774521334902,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker that is increasingly used for evaluation of systemic inflammation. This study was performed to investigate whether suPAR may possess a diagnostic value in patients with ventilator\u2010associated pneumonia (VAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This clinical study was performed in the anesthesia intensive care units (ICUs) of our university. In addition to descriptive data, WBC, serum levels of C\u2010reactive protein (CRP) and suPAR prior to and after development of VAP were noted and compared in 31 patients (22 men, 9 women) diagnosed with VAP (Study Group) and 19 patients without VAP (Control Group) in ICU (14 men, 5 women).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The suPAR (<jats:italic>P<\/jats:italic>\u2009=\u20090.023), CRP (<jats:italic>P<\/jats:italic>\u2009=\u20090.037), WBCs (<jats:italic>P<\/jats:italic>\u2009=\u20090.024) in patients with VAP were significantly higher than patients without VAP. There was no remarkable difference in terms of WBCs (<jats:italic>P<\/jats:italic>\u2009=\u20090.052) and suPAR levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.616) between groups on the first day of connection to mechanical ventilator. The suPAR and CRP levels in patients with VAP were significantly higher than prior to development of VAP (<jats:italic>P<\/jats:italic>\u2009=\u20090.001 for both). Area under curve value after diagnosis of pneumonia was found 0.248 (<jats:italic>P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To conclude, our results suggest that suPAR can be a useful diagnostic biomarker in patients with VAP. However, clinical trials on larger series are warranted to explore the clinical significance more accurately.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12438","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T08:11:02Z","timestamp":1450512662000},"page":"925-930","source":"Crossref","is-referenced-by-count":6,"title":["Could soluble urokinase plasminogen receptor (suPAR) be used as a diagnostic biomarker for ventilator\u2010associated pneumonia?"],"prefix":"10.1111","volume":"11","author":[{"given":"Aysel","family":"Sunnetcioglu","sequence":"first","affiliation":[{"name":"Department of Chest Diseases Yuzuncu Yil University Medical Faculty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"Sunnetcioglu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Yuzuncu Yil University Medical Faculty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u0131rat","family":"Ad\u0131yaman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Yuzuncu Yil University Medical Faculty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan","family":"Binici","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Ercis State Hospital Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokman","family":"Soyoral","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Yuzuncu Yil University, Medical Faculty Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Soluble urokinase plasminogen activator receptor: an indicator of pneumonia severity in children","volume":"835","author":"Wrotek A","year":"2015","journal-title":"Adv Exp Med Biol."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2014.12.018"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000724"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2010.12.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.08.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-644ST"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000724"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304754"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2613-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02372.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.00850.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10037"},{"key":"e_1_2_6_15_1","first-page":"357","article-title":"Soluble urokinase type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD","volume":"10","author":"Gumus A","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-3056-z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3924-9"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12438","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:49:31Z","timestamp":1695563371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,9]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/crj.12438"],"URL":"https:\/\/doi.org\/10.1111\/crj.12438","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,9]]}}}