{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:53:05Z","timestamp":1791816785738,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81172782"],"award-info":[{"award-number":["81172782"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Science and Technology Commission Foundation","award":["14411964800"],"award-info":[{"award-number":["14411964800"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship of pathogen DNA copies with clinic and laboratory features among children with Mycoplasma pneumoniae (MP) pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 95 enrolled children with MP pneumonia were assigned into the high\u2010MP\u2010load group (&gt;10<jats:sup>6<\/jats:sup>\/mL) and the low\u2010MP\u2010load group (\u226410<jats:sup>6<\/jats:sup>\/mL) according to MP\u2010DNA copies in bronchoalveolar lavage fluid (BALF). Clinical characteristics and any allergy history were collected. Aeroallergens and food allergens were detected with a skin test. Serum IgE and eosinophil cationic protein (ECP) were assessed using enzyme immunoassay. BALF levels of IL\u20104, IFN\u2010\u03b3, IL\u20108 and TNF\u2010\u03b1 were assessed by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the low\u2010MP\u2010load group, 72.7% in the high\u2010MP\u2010load group developed refractory MP pneumonia who failed to respond to at least 1\u2010week treatment with macrolides (72.7% vs 41.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.005). More children in the high\u2010load group than those in the low\u2010load group presented with extrapulmonary manifestations, lung consolidation, pleural effusion and atopic conditions including any allergy history, positive findings of aeroallergen test and increased serum IgE and ECP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). A significant higher BALF IL\u20104 level was seen in the high\u2010load group versus the low\u2010load group (23.00\u2009\u00b1\u200911.24 vs 14.68\u2009\u00b1\u20097.12; pg\/mL; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). There were no significant differences in BALF levels of IFN\u2010\u03b3, IL\u20108 and TNF\u2010\u03b1 between the two groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Atopy may be a risk factor for the presence and severity of refractory MP pneumonia due to the high pathogen load in airway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12439","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T08:18:35Z","timestamp":1450513115000},"page":"931-934","source":"Crossref","is-referenced-by-count":14,"title":["Atopy: a risk factor of refractory mycoplasma pneumoniae pneumonia?"],"prefix":"10.1111","volume":"11","author":[{"given":"Yi\u2010Xiao","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Pediatric Respirology &amp; Immunology Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road Shanghai 200092 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respirology &amp; Immunology Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road Shanghai 200092 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respirology &amp; Immunology Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road Shanghai 200092 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang\u2010Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respirology &amp; Immunology Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road Shanghai 200092 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respirology &amp; Immunology Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road Shanghai 200092 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2008.06.012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702007000500012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3343"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.091724"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2014.57.6.271"},{"key":"e_1_2_7_7_1","first-page":"736","article-title":"Relationship between bronchoalveolar lavage mycoplasma load and clinical characteristics in children with Mycoplasma pneumoniae pneumonia","volume":"51","author":"Cheng YG","year":"2013","journal-title":"Zhonghua Er Ke Za Zhi."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00737-13"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02060-12"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22706"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-39"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/rr40"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.3.1786"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00410"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-591"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12439","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:50:43Z","timestamp":1695563443000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/crj.12439"],"URL":"https:\/\/doi.org\/10.1111\/crj.12439","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}