{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:47:55Z","timestamp":1791478075776,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Idiopathic pulmonary hemosiderosis (IPH) is a rare disorder of unknown etiology which can cause diffuse alveolar hemorrhage. IPH is found primarily in children. In adults, however, it is extremely rare. A systematic review was applied to identify the details of IPH in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Articles of English or Chinese language published between 2000 and 2015 were included. Data were extracted on the clinical features, examinations, treatments and clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 37 cases of adult\u2010onset IPH were included (13 females and 24 males). IPH combined with coeliac disease was found in five patients, three of whom received gluten\u2010free diet (GFD) only and got full remission. Upon diagnosis, median age was 34 years. The main manifestations were: hemoptysis (<jats:italic>n<\/jats:italic>\u2009=\u200930, 81%), dyspnea (<jats:italic>n<\/jats:italic>\u2009=\u200923, 64%), anemia (<jats:italic>n<\/jats:italic>\u2009=\u200920, 54%). Most patients were treated by corticosteroids initially. The mortality rage was 14% on acute phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The adult patients in this study showed some differences from the previously characterized IPH. It is characterized by immunologically mediated, middle\u2010age onset, male dominance, absence of anemia, high mortality on acute phase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12440","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T16:15:15Z","timestamp":1450714515000},"page":"677-681","source":"Crossref","is-referenced-by-count":47,"title":["Idiopathic pulmonary hemosiderosis in adults: review of cases reported in the latest 15 years"],"prefix":"10.1111","volume":"11","author":[{"given":"Xi\u2010Yuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Zhejiang Provincial People's Hospital Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Ming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The People's No.3 Hospital of Hangzhou Xiaoshan Hangzhou 311251 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Zhejiang Provincial People's Hospital Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00116302"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000007027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40783-9"},{"issue":"3","key":"e_1_2_6_5_1","first-page":"211","article-title":"Idiopathic pulmonary haemosiderosis in an adult. 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