{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:28:43Z","timestamp":1771306123663,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of pulmonary manifestations of ANCA\u2010associated vasculitis (AAV) is not well understood. This study describes the prevalence of respiratory complications of AAV detected via imaging in patients presenting to a secondary renal centre and describes the associations with mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>105 patients with AAV were identified from the Chronic Renal Insufficiency Standards Implementation Study (CRISIS). CRISIS is a prospective epidemiological study of patients with chronic kidney disease stages 3\u20135, both who did and did not require dialysis on presentation. Patients were recruited between 2000 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A chest X\u2010ray was performed in 81.0% of patients with AAV on presentation, of which 56.5% were abnormal. A computed tomography (CT) thorax was performed in 27 patients during the course of their disease: 92.6% showed abnormalities, most commonly fibrosis (63.0%) and bronchiectasis (44.4%). Pulmonary vascultitis was confirmed in 22 of 105 patients (21.0%) after respiratory review or demonstrated by associated changes associated on CT scan. In a Cox regression model, there was no significant association between pulmonary vasculitis and mortality (<jats:italic>P<\/jats:italic>\u2009=\u20090.088), although there was a trend towards increased mortality with pulmonary vasculitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pulmonary manifestations of AAV were common, however only a small proportion of patients had had thorough respiratory investigations, suggesting that the pulmonary manifestations of AAV may be under\u2010diagnosed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12478","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T12:41:47Z","timestamp":1460292107000},"page":"57-61","source":"Crossref","is-referenced-by-count":11,"title":["Respiratory manifestations of ANCA\u2010associated vasculitis"],"prefix":"10.1111","volume":"12","author":[{"given":"Kerry","family":"Greenan","sequence":"first","affiliation":[{"name":"School of Medicine University of 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