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It was reported that XPA rs1800975 polymorphism was associated with susceptibility to lung cancer. However, the conclusions were controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a computer retrieval of PubMed, EMbase, CNKI, CBM, and WanFang infrastructure platform from 1980 to 2014. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association strength. Publication bias was detected by means of a funnel plot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 11 articles (12 studies) involving 4257 cases and 5294 controls were included. Significant associations could be found between rs1800975 and lung cancer risk in these three models (codominant model AG vs. AA, overdominant genetic model AG vs. AA\u2009+\u2009GG, dominant model AG\u2009+\u2009GG vs. AA) in overall. In the stratified analysis by ethnicity, we found similar results as above in the Asian population. In the smoking population, the G allele carriers were associated with a significantly reduced risk of lung cancer (AG\u2009+\u2009GG vs. AA) compared with the AA carriers\uff0eStratified analysis showed the AG genotype and G allele carriers (AG\u2009+\u2009GG) might be a protective factor compared with the AA gene for squamous carcinoma (AG vs. AA, AG\u2009+\u2009GG vs. AA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis suggested that the XPA gene rs1800975 Polymorphism was associated with lung cancer susceptibility. By performing multiple separate pairwise comparisons, carriers with AG genotype under the codominant genetic model (AG vs. AA) might play actually the leading role in associating with lung cancer susceptibility in overall and in Asians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12535","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T08:33:26Z","timestamp":1469608406000},"page":"448-458","source":"Crossref","is-referenced-by-count":4,"title":["Association between XPA gene rs1800975 polymorphism and susceptibility to lung cancer: a meta\u2010analysis"],"prefix":"10.1111","volume":"12","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Fujian province geriatric Hospital Fuzhou 350000 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qunying","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Affiliated Hospital of Putian University Putian 351100 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiping","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Zhongshan Hospital, Fudan University Shanghai 200032 People's Republic of China"},{"name":"Respiratory Research Institute, Fudan University Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Affiliated Jiangyin Hospital of Southeast University Jiangyin 214400 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Zhongshan Hospital, Fudan University Shanghai 200032 People's Republic of China"},{"name":"Respiratory Research Institute, Fudan University Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Zhongshan Hospital, Fudan University Shanghai 200032 People's Republic of China"},{"name":"Respiratory Research Institute, Fudan University Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanqun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Zhongshan Hospital, Fudan University Shanghai 200032 People's Republic of China"},{"name":"Respiratory Research Institute, Fudan University Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai 200032 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1440"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/24.3.505"},{"key":"e_1_2_9_4_1","first-page":"246","article-title":"The single nucleotide polymorphism in the promotor of DNA repair gene XPA and in association with the risk of lung cancer","volume":"25","author":"Zhu JF","year":"2005","journal-title":"Zhong Liu."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi232"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.4.59"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-0878-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02125.x"},{"key":"e_1_2_9_9_1","unstructured":"WellsGA SheaB O'ConnellD et al. 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