{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:22:25Z","timestamp":1780104145223,"version":"3.54.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:italic>Mycobacterium abscessus<\/jats:italic> infection in cystic fibrosis (CF) patients can lead to poor outcomes. Early diagnosis is important, but there are no studies outlining specific imaging features of <jats:italic>M. abscessus<\/jats:italic> in CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the computed tomography (CT) findings of early <jats:italic>M. abscessus<\/jats:italic> infection in our CF population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen CF patients with sputum cultures positive for <jats:italic>M. abscessus<\/jats:italic> from 2006 to 2013 were identified at our institution. Clinical characteristics including culture dates and lung function were reviewed. Positive cultures were classified as \u201cdisease\u201d versus \u201ccolonization\u201d based on published criteria. Chest CT scans were reviewed at times closest to initial infection, and features including bronchiectasis, mucous plugging, consolidation, ground glass opacities, nodules, and cavitation were evaluated. Brody scores were calculated to evaluate extent of CF lung disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had bronchiectasis and mucous plugging, with 10 of 13 (76.9%) in an upper lobe distribution. Consolidation was seen in 12 of 13 (92.3%) patients, 8 (61.5%) patients had nodules, and 5 (38.5%) with cavitation. The average Brody score was 59.5, which was no different than previously described CF cohorts without <jats:italic>M. abscessus<\/jats:italic>. There were no significant differences between subjects with disease versus colonization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The most common CT features of early <jats:italic>M. abscessus<\/jats:italic> in our CF population include bronchiectasis, mucus plugging, and consolidation, but the findings did not reveal a unique radiologic signature. CT at this initial time point may not distinguish early <jats:italic>M. abscessus<\/jats:italic> infection from background lung disease or mycobacterial colonization in CF patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12536","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T08:33:34Z","timestamp":1469608414000},"page":"459-466","source":"Crossref","is-referenced-by-count":3,"title":["Radiologic computed tomography features of <i>Mycobacterium abscessus<\/i> in cystic fibrosis"],"prefix":"10.1111","volume":"12","author":[{"given":"Diana L.","family":"Lam","sequence":"first","affiliation":[{"name":"Department of Radiology University of Washington School of Medicine Seattle WA 98195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha G.","family":"Kapnadak","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine University of Washington School of Medicine Seattle WA 98195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. David","family":"Godwin","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Washington School of Medicine Seattle WA 98195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Kicska","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Washington School of Medicine Seattle WA 98195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira L.","family":"Aitken","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine University of Washington School of Medicine Seattle WA 98195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhakar N.","family":"Pipavath","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Washington School of Medicine Seattle WA 98195 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"2013 Annual Data Report","author":"Cystic Fibrosis Foundation Patient Registry.","year":"2014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043184"},{"issue":"2","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1128\/JCM.39.2.816-819.2001","article-title":"Fatal pulmonary infection due to multidrug\u2010resistant Mycobacterium abscessus in a patient with cystic fibrosis","volume":"39","author":"Sanguinetti M","year":"2001","journal-title":"J Clin Microbiol."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9903062"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000163311.70464.91"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201002-0310OC"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-404OC"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-678OC"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-679OC"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.12.001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0704OC"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.185.2.231"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60632-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.08.023"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.181.2.1810513"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.02.038"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rti.0000203937.82276.ce"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03686.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2003.131106"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111374"},{"issue":"1","key":"e_1_2_8_24_1","first-page":"18","article-title":"The correlation of Brody high resolution computed tomography scoring system with clinical status and pulmonary function test in patients with cystic fibrosis","volume":"36","author":"Khalilzadeh S","year":"2011","journal-title":"Iran J Med Sci."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.110908"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12536","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:46:55Z","timestamp":1695484015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,22]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/crj.12536"],"URL":"https:\/\/doi.org\/10.1111\/crj.12536","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,22]]}}}