{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:14:36Z","timestamp":1695528876150},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Growing evidence suggests a role of vitamin D in various cancers but the significance of vitamin D in malignant pleural disease remains unexplored. We sought to investigate the concentration and diagnostic role of 25\u2010hydroxyvitamin D (25(OH)D) in malignant pleural effusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Prospective study of consecutive treatment\u2010na\u00efve patients with a new diagnosis of pleural effusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010eight patients were studied, 45 of whom had malignant pleural effusions. Concentration of 25(OH)D in pleural fluid was significantly higher than serum in both malignant (15.2 ng\/mL (9.7, 25.6) versus 10.2 ng\/mL (6.4, 17.7), <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and benign (11.4 ng\/mL (8.4, 23.6) versus 7.9 (5.9, 16.1), <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) pleural disease. Pleural fluid 25(OH)D was almost significantly higher in exudates compared to transudates (<jats:italic>P<\/jats:italic>\u2009=\u2009.050) but it did not differ significantly between malignant and benign effusions (<jats:italic>P<\/jats:italic>\u2009=\u2009.217) and it was not diagnostic for malignant pleural disease (area under the ROC curve .58, 95% CI .45\u2010.71).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In subjects with unselected pleural effusions, 25(OH)D in pleural fluid was not diagnostic for malignant pleural disease. The novel finding of convincingly and consistently higher 25(OH)D in pleural fluid than serum suggests a role for vitamin D in pleural disease and merits further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12540","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T08:29:12Z","timestamp":1470731352000},"page":"467-473","source":"Crossref","is-referenced-by-count":0,"title":["25\u2010hydroxyvitamin D in malignant pleural disease: a prospective cohort study"],"prefix":"10.1111","volume":"12","author":[{"given":"Marios","family":"Panagiotou","sequence":"first","affiliation":[{"name":"2nd Respiratory Medicine Department Sismanoglio General Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andriana I.","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"2nd Respiratory Medicine Department Sismanoglio General Hospital Athens 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