{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:02:48Z","timestamp":1787166168368,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Municipal Administration of Hospitals' Youth Programme","award":["QML 20150301"],"award-info":[{"award-number":["QML 20150301"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The important role of radiological examinations of invasive pulmonary aspergillosis (IPA) in patients with neutropenia has been well studied; however, little is known about IPA in critically ill chronic obstructive pulmonary disease (COPD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the value of radiological examinations in the diagnosis and prognosis of invasive bronchial\u2010pulmonary aspergillosis (IBPA) in critically ill COPD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 61 critically ill COPD patients in the intensive care unit (ICU) in a retrospective, single\u2010center cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All of the patients were classified as IBPA group (n\u2009=\u200921) or non\u2010IBPA group (n\u2009=\u200940). The chest computed tomography (CT) image analysis showed that the IBPA group had the highest percent of patchiness (76.2%), followed by multiple nodules (33.3%), angio\u2010invasive patterns (including halo sign, wedge consolidation and air\u2010crescent sign\/cavity with a relatively low percent of 19%, 19% and 28.5%, respectively), and the multiple nodules that were distributed along the airway provided the most specific image, with the highest specificity of 92.5%. Compared to the survivors in the IBPA group, non\u2010surviving patients had a higher percent of large consolidation (0% vs. 45.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.035). When the new effusions appeared on a chest x\u2010ray (CXR), the creatinine (140.4 \u03bcmol\/L vs. 64.0 \u03bcmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.010) and PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      (188 mm Hg vs. 222 mm Hg,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.034) rate deteriorated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multiple nodules that were distributed along with broncho\u2010vascular bundles were relatively common and specific in critically ill COPD patients with IBPA. Deteriorated CXR combined with specific laboratory examinations, even when appropriate antibiotics were used, could indicate a diagnosis of IBPA. Large consolidations might be considered as poor prognostic indicators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.12551","type":"journal-article","created":{"date-parts":[[2016,9,10]],"date-time":"2016-09-10T11:26:43Z","timestamp":1473506803000},"page":"499-509","source":"Crossref","is-referenced-by-count":28,"title":["Values of radiological examinations for the diagnosis and prognosis of invasive bronchial\u2010pulmonary aspergillosis in critically ill patients with chronic obstructive pulmonary diseases"],"prefix":"10.1111","volume":"12","author":[{"given":"Linna","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing P.R. China"},{"name":"Department of Respiratory and Critical Care Medicine, China\u2010Japan Friendship Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangyong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine, Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, China\u2010Japan Friendship Hospital Beijing P.R. 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