{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:05:36Z","timestamp":1758265536373,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","award":["20124270"],"award-info":[{"award-number":["20124270"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) has emerged as a minimally invasive technique for diagnosing intrathoracic malignancies and some benignancies; however, there are no data available on the utility of EBUS\u2010TBNA for the diagnosis of non\u2010specific inflammatory intrathoracic lymphadenitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective analysis was performed from 104 patients with enlarged lymphadenopathy suspected of non\u2010specific lymphadenitis referred for EBUS\u2010TBNA between October 2009 and March 2012. Rapid on\u2010site cytological evaluation was not adopted. Microbiological tests were carried out in all patients. Patients were excluded from the study if there was other diagnosis being defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred ninety\u2010one lesions were aspirated in 94 patients with enlarged mediastinal\/hilar lymph nodes within reach of EBUS\u2010TBNA, which were diagnosed as non\u2010specific intrathorcacic lymphadenitis by pathology and clinical follow\u2010up. According to EBUS\u2010TBNA pathologies, 94 patients were categorized into four kinds: (i) inflammatory cell infiltrates and\/or noncaseating necrosis in 38 cases; (ii) granuloma formed by epithelioid cells and\/or fiber hyperplasia in 13 cases; (iii) lymph node tissue\/lymphocyte without obvious abnormal lesions in 41 cases; (iv) inadequate sample in 2 cases. Bacterial and\/or fungal smears and cultures were carried out in all 94 patients (100%), with pathogens being found in 4 (4.3%) cases. All patients (100%) underwent acid\u2010fast staining and culture for mycobacterium tuberculosis to exclude tuberculosis. No procedure\u2010related complication was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EBUS\u2010TBNA can provide pathological and microbiological evidences for diagnosing non\u2010specific inflammatory intrathoracic lymphadenopathy, and it is a safe and effective first\u2010line investigation for ruling out malignancies and other benign diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12580","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T17:17:04Z","timestamp":1478539024000},"page":"691-698","source":"Crossref","is-referenced-by-count":6,"title":["Utility of endobronchial ultrasound\u2010guided transbronchial needle aspiration in diagnosing non\u2010specific inflammatory intrathorcacic lymphadenitis"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-8022","authenticated-orcid":false,"given":"Huizhen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Endoscopy Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai 200030 People's Republic of China"},{"name":"Department of Respiratory and Critical Care Medicine People's Hospital of Zhengzhou University Zhengzhou 450003 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine First People's Hospital of Yunnan Province Kunming 650000 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai 200030 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baohui","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai 200030 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai 200030 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2004.2.131"},{"key":"e_1_2_8_3_1","first-page":"2363","volume-title":"General Thoracic Surgery","author":"Olak J.","year":"2009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1216"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.175884"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-699X.2011.00251.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.6082"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.07.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2355"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142336"},{"key":"e_1_2_8_11_1","first-page":"1818","article-title":"First 30 endobronchial ultrasound\u2010guided transbronchial needle aspirations: a single institution's early experience","volume":"124","author":"Sun JY","year":"2011","journal-title":"Chin Med J (Engl)."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1759-7714.2010.00010.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181a0d82e"},{"key":"e_1_2_8_14_1","first-page":"1","volume-title":"Bureau of Disease Control and Prevention, Bureau of Medical Administration, Chinese Center for Disease Control and Prevention. 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