{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:59:00Z","timestamp":1760385540160},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271840\/H1904"],"award-info":[{"award-number":["81271840\/H1904"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The inflammatory marker patterns of community\u2010acquired Pneumonia (CAP) induced by different microorganisms in adult patients remained unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aim to explore the inflammatory marker patterns of adult CAP patients induced by different pathogens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult CAP patients with definite etiologies were enrolled from September 2010 to June 2012. They were divided into three groups according to the causative pathogens: typical bacteria, <jats:italic>Mycoplasma pneumoniae<\/jats:italic> (MP), and viruses. Twenty\u2010seven cytokines and bactericidal\/permeability\u2010increasing protein (BPI) levels of serum collected within 7 days onset in these groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred twenty\u2010four cases were enrolled for serum detection and analysis, including 10 typical bacterial pneumonia patients, 56 cases with MP pneumonia and 58 with viral pneumonia. Three kinds (PDGF\u2010BB, IP\u201010, RANTES) of 27 cytokines and BPI levels were significantly elevated in patients with acute pneumonia than healthy controls. Distinct inflammatory marker patterns were released by different pathogens: typical bacterial pneumonia patients had highest levels of BPI, IL\u20106, IL\u20108, IL\u20101r\u03b1; while patients caused by MP presented higher levels of PDGF\u2010BB, IL\u201017A, G\u2010CSF than those caused by viruses. Rhinovirus owned a higher inflammatory response level than the other viruses. The area under the curve (AUC) of PDGF\u2010BB to differentiate MP and virus infection was biggest, which was 0.708.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distinct inflammatory marker patterns were released by different pathogens during acute pneumonia. Significantly increased level of PDGF\u2010BB was observed in acute pneumonia for the first time. It showed a better ability to differentiate MP and virus infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12614","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T11:34:35Z","timestamp":1485862475000},"page":"974-985","source":"Crossref","is-referenced-by-count":12,"title":["Differences in inflammatory marker patterns for adult community\u2010acquired pneumonia patients induced by different pathogens"],"prefix":"10.1111","volume":"12","author":[{"given":"Meng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Infectious diseases and Clinical Microbiology Beijing Chao\u2010Yang Hospital, Beijing Institute of Respiratory Medicine Beijing 100020 China"},{"name":"Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University Beijing 100010 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory 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