{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:13:18Z","timestamp":1776211998723,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T00:00:00Z","timestamp":1486944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the diagnostic value of joint detection of soluble B7\u2010H4 (sB7\u2010H4) and carcinoembryonic antigen (CEA) in identifying malignant pleural effusion (MPE) from benign pleural effusion (BPE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 97 patients with pleural effusion specimens were enrolled from The First Affiliated Hospital of Zhengzhou University between June 2014 and December 2015. All cases were categorized into malignant pleural effusion group (<jats:italic>n<\/jats:italic>\u00a0=\u00a055) and benign pleural effusion group (<jats:italic>n<\/jats:italic>\u00a0=\u00a042) according to etiologies. Enzyme\u2010linked immunosorbent assay was applied to examine the levels of sB7\u2010H4 in pleural effusion and meanwhile CEA concentrations were detected by electro\u2010chemiluminescence immunoassays. Receiver operating characteristic (ROC) curve was established to assess the diagnostic value of sB7\u2010H4 and CEA in pleural effusion. The correlation between sB7\u2010H4 and CEA levels was analyzed by Pearson's product\u2010moment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentrations of sB7\u2010H4 and CEA in MPE exhibited obviously higher than those of BPE ([60.08\u00a0\u00b1\u00a035.04] vs. [27.26\u00a0\u00b1\u00a09.55]\u00a0ng\/ml, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000; [41.49\u00a0\u00b1\u00a037.16] vs. [2.41\u00a0\u00b1\u00a00.94]\u00a0ng\/ml, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000). The AUC area under ROC curve of sB7\u2010H4 and CEA was 0.884 and 0.954, respectively. Two cutoff values by ROC curve analysis of sB7\u2010H4 36.5\u00a0ng\/ml and CEA 4.18\u00a0ng\/ml were obtained, with a corresponding sensitivity (81.82%, 87.28%), specificity (90.48%, 95.24%), accuracy (85.57%, 90.72%), positive predictive value (PPV) (91.84%, 96.0%), negative predictive value (NPV) (79.17%, 85.11%), positive likelihood ratio (PLR) (8.614, 18.327), and negative likelihood ratio (NLR) (0.201, 0.134). When sB7\u2010H4 and CEA were combined to detect pleural effusion, it obtained a higher sensitivity 90.91% and specificity 97.62%. Furthermore, correlation analysis result showed that the level of sB7\u2010H4 was correlated with CEA level (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.770, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>sB7\u2010H4 was a potentially valuable tumor marker in the differentiation between BPE and MPE. The combined detection of sB7\u2010H4 and CEA could improve the diagnostic sensitivity and specificity for MPE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12615","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T08:53:43Z","timestamp":1485507223000},"page":"986-990","source":"Crossref","is-referenced-by-count":8,"title":["Diagnostic value of soluble B7\u2010H4 and carcinoembryonic antigen in distinguishing malignant from benign pleural effusion"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-4524","authenticated-orcid":false,"given":"Xiaogang","family":"Jing","sequence":"first","affiliation":[{"name":"Department of Respiratory The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 People's Republic of China"},{"name":"Institute of Clinical Medicine The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 People's Republic of 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