{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:59:23Z","timestamp":1788976763321,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T00:00:00Z","timestamp":1502582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To define the characteristics of necrotizing sarcoid granulomatosis (NGS) a very rare pulmonary disease hardly recognised by pulmonologists and pathologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data source<\/jats:title><jats:p>PubMed was searched for the term necroti<jats:bold>s<\/jats:bold>ing or necroti<jats:bold>z<\/jats:bold>ing sarcoid granulomatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study selection<\/jats:title><jats:p>All cases reported in the English literature were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NGS is presented at all ages (range 8\u201068 years) with a median age of 42 years old. It shows female (62%) and Caucasian (80%) predominance. The most frequent symptoms are cough, fever, dyspnoea and chest pain. Extra\u2010pulmonary involvement is found in one third of the cases, with ocular being the most common (12.5%). At imaging, multiple nodules (64.75%) or a solitary mass (20.49%) are found accompanied by mediastinal lymphadenopathy at one third of the cases. It can be clinically mistaken for malignancy as it is tumour\u2010like, increases rapidly in size and it is hyperfixating in PET\u2010SCAN. Histologically, NGS is defined by large areas of necrosis, well\u2010formed granulomas and vascularitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NGS is a disease often confounded clinically with malignancy or with sarcoidosis even histologically when all criteria are not strictly applied. This review provides NGS' characteristics and discusses its differential diagnosis form sarcoidosis, Wegener granulomatosis and tuberculosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12673","type":"journal-article","created":{"date-parts":[[2017,7,30]],"date-time":"2017-07-30T03:36:37Z","timestamp":1501385797000},"page":"1313-1319","source":"Crossref","is-referenced-by-count":46,"title":["Necrotizing sarcoid granulomatosis: A distinctive form of pulmonary granulomatous disease"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-935X","authenticated-orcid":false,"given":"Georgia","family":"Karpathiou","sequence":"first","affiliation":[{"name":"Department of Pathology University Hospital of St\u2010Etienne Saint Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Batistatou","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Ioannina Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Boglou","sequence":"additional","affiliation":[{"name":"Department of Pneumonology Democritus University of Thrace Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Stefanou","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Ioannina Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8758-666X","authenticated-orcid":false,"given":"Marios E.","family":"Froudarakis","sequence":"additional","affiliation":[{"name":"Department of Pneumonology Democritus University of Thrace Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,13]]},"reference":[{"issue":"5","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.5858\/134.5.667","article-title":"Granulomatous lung disease: an approach to the differential diagnosis","volume":"134","author":"Mukhopadhyay S","year":"2010","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02546.x"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"1","article-title":"The J. 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