{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:51:58Z","timestamp":1781221918359,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600032"],"award-info":[{"award-number":["81600032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["15YF1409700"],"award-info":[{"award-number":["15YF1409700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite using vasoactive and pulmonary hypertension (PH) specific therapies, the in\u2010hospital mortality of severe PH with right heart failure (RHF) is high. We conducted a prospective analysis evaluating the efficacy and safety of levosimendan in PH patients with severe acute RHF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five PH patients hospitalized between January 2016 and November 2016 were recruited into a single arm, prospective, open\u2010label study. Levosimendan was administered at the rate of .05\u20130.1 \u03bcg\/kg\/min, up to a total dose of 12.5 mg. The primary endpoints were changes of World Health Organization Function Class (WHO\u2010FC) and Borg dyspnoea scores. Secondary endpoints included changes in 6\u2010min walk distance (6\u2010MWD), biochemical markers and right heart structure and function together with adverse events on day 7 and incidence of major cardiovascular events (death or readmission due to RHF) on day 30.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five PH patients were enrolled. On the 7th day after levosimendan infusion, seven out of 13 PH patients with WHO\u2010FC IV improved by one class (<jats:italic>P<\/jats:italic>\u2009=\u2009.008). Borg dyspnoea scores, 6\u2010MWD and NT\u2010proBNP improved significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Compared with baseline, the right atrial transverse dimension, end\u2010systolic eccentricity index and tricuspid annular plane systolic excursion improved significantly (58.8\u2009\u00b1\u200913.1 mm vs 53.7\u2009\u00b1\u200912.4 mm; 1.50\u2009\u00b1\u20090.27 vs 1.38\u2009\u00b1\u20090.23; 15.0 (13.0, 16.0) mm vs 15.8 (14.0, 17.4) mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.005, respectively). One patient occurred sudden death after discharge during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravenous levosimendan can effectively improve severe RHF of PH patients in hospital and well tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12699","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T09:18:39Z","timestamp":1504257519000},"page":"1518-1525","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy and safety of a calcium sensitizer, levosimendan, in patients with right heart failure due to pulmonary hypertension"],"prefix":"10.1111","volume":"12","author":[{"given":"Rong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-8880","authenticated-orcid":false,"given":"Qin\u2010Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Circulation Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai 200433 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