{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:15:27Z","timestamp":1780499727547,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Brooke Army Medical Center Department of Clinical Investigation, San Antonio, TX","award":["413707"],"award-info":[{"award-number":["413707"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acute pulmonary exacerbations of cystic fibrosis (APECF) are a leading cause of morbidity and mortality among patients with cystic fibrosis (CF). APECF require frequent administration of antibiotics and subsequently lead to development of resistant organisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to identify inflammatory markers that may be help identify need for antibiotics and exacerbation as well as predict risk of exacerbations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 17 patients were enrolled, and baseline erythrocyte sedimentation rate (ESR), C\u2010reactive protein (CRP) and procalcitonin levels were obtained in addition to obtaining these levels during admissions for APECF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 28 APECF were recorded. ESR and CRP significantly increased during exacerbation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01 for both). Procalcitonin did not increase during exacerbations. Baseline elevations in ESR and CRP increased risk of an exacerbation (RR\u00a0=\u00a02.3 and 4.5, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ESR and CRP are useful markers for CF exacerbations, as levels rise with exacerbations. Baseline elevations in ESR and CRP were noted to show an increased risk for CF exacerbations. Procalcitonin, in contrast, is not a useful inflammatory marker.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12703","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T03:42:54Z","timestamp":1504842174000},"page":"1545-1549","source":"Crossref","is-referenced-by-count":14,"title":["Procalcitonin, erythrocyte sedimentation rate and C\u2010reactive protein in acute pulmonary exacerbations of cystic fibrosis"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0086-6085","authenticated-orcid":false,"given":"Geoffrey","family":"Loh","sequence":"first","affiliation":[{"name":"Pulmonary\/Critical Care San Antonio Military Medical Center Fort Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Ryaboy","sequence":"additional","affiliation":[{"name":"Internal Medicine San Antonio Military Medical Center Fort Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Skabelund","sequence":"additional","affiliation":[{"name":"Pulmonary\/Critical Care San Antonio Military Medical Center Fort Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"French","sequence":"additional","affiliation":[{"name":"Clinical Nurse Coordinator for Tri\u2010Services Cystic Fibrosis Center at San Antonio Military Medical Center Fort Sam Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283631046"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1845PP"},{"key":"e_1_2_10_4_1","first-page":"CD006682","article-title":"Duration of intravenous antibiotic therapy in people with cystic fibrosis","volume":"9","author":"Plummer A","year":"2016","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.060889"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-204000"},{"key":"e_1_2_10_7_1","first-page":"CD007498","article-title":"Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections","volume":"9","author":"Schuetz P","year":"2012","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2067"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1502-x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.06.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0693"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479972308088823"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2016.10.011"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.12703","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T16:22:40Z","timestamp":1693844560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,19]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/crj.12703"],"URL":"https:\/\/doi.org\/10.1111\/crj.12703","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,19]]}}}