{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:28:03Z","timestamp":1790803683728,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prognosis of patients with an acute exacerbation of interstitial pneumonia (AE\u2010IP) is poor. Pirfenidone (PFD) reduces the disease progression in idiopathic pulmonary fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was evaluating whether the administration of PFD improved the outcomes of AE\u2010IP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of 31 patients with AE\u2010IP who did not recover between 7 and 14\u00a0days after an initial treatment. Fourteen patients received PFD within 2\u00a0weeks (PFD group) of the AE, while 17 patients were treated without PFD (non\u2010PFD group). The patients\u2019 clinical data and computed tomography (CT) scores were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The survival rate in the PFD group was not significantly different from non\u2010PFD group at 30 (78.6% vs 64.7%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.46) and 90\u00a0days (64.3% vs 52.9%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.72). The white blood cell counts in the PFD group were significantly lower on PFD day 14 than on PFD days 1 and 7. The C\u2010reactive protein levels in the PFD group were also significantly lower on PFD day 7 than on PFD day 1. There were no significant differences regarding the changes of the CT scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PFD may reduce the inflammation in AE\u2010IP patients undergoing corticosteroid treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12704","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T14:42:44Z","timestamp":1504708964000},"page":"1550-1558","source":"Crossref","is-referenced-by-count":14,"title":["The effects of pirfenidone in patients with an acute exacerbation of interstitial pneumonia"],"prefix":"10.1111","volume":"12","author":[{"given":"Takuma","family":"Matsumura","sequence":"first","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University, Inohana 1\u20108\u20101 Chuo\u2010ku Chiba 260\u20108670 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