{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:51:49Z","timestamp":1778917909926,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the characteristics of patients who developed tuberculosis while receiving tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) antagonists and the related factors with tuberculosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient's demographics, tuberculin skin test (TST), isoniazid prophylaxis and type of TNF\u2010\u03b1 antagonist were recorded. TST conversion (\u22655\u00a0mm increase) was evaluated for patients who had baseline and 1\u2010year TST.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Files of 1887 patients who were receiving TNF\u2010\u03b1 antagonists between August 2005 and June 2015 were evaluated. TST significantly increased at the end of 1\u00a0year (<jats:italic>n<\/jats:italic>\u00a0=\u00a0748 baseline:7.36\u00a0\u00b1\u00a07.2\u00a0mm vs. 1\u00a0year:9.52\u00a0\u00b1\u00a07.5\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). One\u2010third of patients (31.2%) who had negative TST at baseline had positive TST at 1\u00a0year. Tuberculosis developed in 22 patients (1.16%). The annual incidence of tuberculosis was 423\/100\u00a0000 patient\u2010year. TNF\u2010\u03b1 antagonist indications were ankylosing spondylitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), inflammatory bovel diseases (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) and rheumatoid arthritis (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). Ten (45.5%) patients received infliximab, six (27.3%) patients received etanercept and six (27.3%) patients received adalimumab. Nineteen (86.4%) patients were under isoniazid prophylaxis. Twelve patients had extrapulmonary tuberculosis (54.5%; four lymph node, three pleura, two periton, one pericarditis, one intestinal, one joint). Atypical mycobacterium was detected in one patient. Adalimumab treatment (9.5\u00d7 increase), male sex (15.6\u00d7 increase) and previous tuberculosis disease history (11.5\u00d7 increase) were risk factors for active tuberculosis. Conversion of TST was not found related with tuberculosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the high proportion of isoniazid prophylaxis, the incidence of tuberculosis in our patients receiving TNF\u2010\u03b1 antagonist was higher than the literature. Adalimumab treatment, male sex and previous tuberculosis disease history were found as risk factors for tuberculosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12726","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T13:02:48Z","timestamp":1507899768000},"page":"1668-1675","source":"Crossref","is-referenced-by-count":21,"title":["Follow\u2010up of 1887 patients receiving tumor necrosis\u2010alpha antagonists: Tuberculin skin test conversion and tuberculosis risk"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9128-3461","authenticated-orcid":false,"given":"Tulin","family":"Cagatay","sequence":"first","affiliation":[{"name":"Department of Pulmonary, Istanbul Medical Faculty, Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuleyha","family":"Bingol","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Istanbul Medical Faculty, Istanbul 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Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feyza","family":"Erkan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Istanbul Medical Faculty, Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziya","family":"Gulbaran","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Istanbul Medical Faculty, Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Erelel","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Istanbul Medical Faculty, Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turhan","family":"Ece","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Istanbul Medical Faculty, Istanbul University Istanbul 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