{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:03:40Z","timestamp":1790193820472,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370159"],"award-info":[{"award-number":["81370159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Asbestos exposure may cause asbestos\u2010related lung diseases including asbestosis, pleural abnormalities and malignancies. The role of asbestos exposure in the development of small airway obstruction remains controversial. Anatomic and physiologic small airway abnormalities may develop as part of the pathophysiologic process of asbestosis. We hypothesized that inhalation of asbestos may induce small airway defects in addition to asbestosis and pleural abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 281 patients with newly diagnosed asbestosis were evaluated. Clinical data were collected from the patients' medical charts. The patients were classified into various stages according to their chest X\u2010ray findings using the International Labour Organization classification. Pulmonary function was evaluated by plethysmography and the forced oscillation technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Expiratory flow, including the predicted values of the maximum expiratory flow between 25% and 50% of the forced vital capacity (MEF<jats:sub>25\u201050<\/jats:sub>), was significantly lower in the different stages of asbestosis. Accordingly, the predicted percentage of<jats:italic>R<\/jats:italic><jats:sub>5<\/jats:sub>\u2013<jats:italic>R<\/jats:italic><jats:sub>20<\/jats:sub>was significantly higher with increasing stages of asbestosis. Furthermore, the duration of exposure to asbestos was significantly associated with the forced expiratory volume in the first second (FEV<jats:sub>1<\/jats:sub>)\/forced vital capacity (FVC) ratio and the predicted percentage of MEF<jats:sub>25<\/jats:sub>or MEF<jats:sub>50<\/jats:sub>according to the regression analysis in non\u2010smoking patients with asbestosis. The predicted percentage of FEV<jats:sub>1<\/jats:sub>or the FEV<jats:sub>1<\/jats:sub>\/FVC ratio was significantly lower and the predicted percentage of<jats:italic>R<\/jats:italic><jats:sub>5<\/jats:sub>\u2013<jats:italic>R<\/jats:italic><jats:sub>20<\/jats:sub>was significantly higher in smokers than non\u2010smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The patients with asbestosis have small airway obstructive defects that are significantly associated with asbestos exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12728","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T11:52:40Z","timestamp":1509450760000},"page":"1676-1684","source":"Crossref","is-referenced-by-count":15,"title":["Association between increased small airway obstruction and asbestos exposure in patients with asbestosis"],"prefix":"10.1111","volume":"12","author":[{"given":"Xiaoli","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongji","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0932-0487","authenticated-orcid":false,"given":"Qiao","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200310-1436ST"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3462"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3471"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12517"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60412-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.11.086678"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.22512"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700050504"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039899809605711"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1815OC"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3.999"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1539\/joh.L10062"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.041s1693"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00089403"},{"key":"e_1_2_9_16_1","unstructured":"International Labour Office. Guidelines for the use of the ILO international classification of radiographs of pneumoconioses. Geneva Switzerland: International Labour Office;2011."},{"key":"e_1_2_9_17_1","first-page":"5","article-title":"Patterns of pulmonary dysfunction in asbestos workers: a cross\u2010sectional study","volume":"3","author":"Abejie BA","year":"2010","journal-title":"J Occup Med Toxicol."},{"key":"e_1_2_9_18_1","first-page":"268","article-title":"Long\u2010term radiological effects of short\u2010term exposure to amosite among factory workers","volume":"49","author":"Ehrlich R","year":"1992","journal-title":"Br J Ind Med."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.5.9707141"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2014-102468"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200172"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(78)90169-X"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000194211"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00203721"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.4.1061"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1345"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2004195"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.1.175"},{"key":"e_1_2_9_29_1","first-page":"31","article-title":"Smoking\u2010associated fibrosis and pulmonary asbestosis","volume":"10","author":"Bledsoe JR","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis."},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3760\/cma.j.issn.0366-6999.20131684","article-title":"Cigarette smoking contributes to idiopathic pulmonary fibrosis associated with emphysema","volume":"127","author":"Ye Q","year":"2014","journal-title":"Chin Med J."}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.12728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T05:08:59Z","timestamp":1719551339000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,23]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/crj.12728"],"URL":"https:\/\/doi.org\/10.1111\/crj.12728","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,23]]}}}