{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:33Z","timestamp":1787014053925,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Most data on transbronchial lung cryobiopsy (TBLC) are from single centers, with little evidence on the outcome of different methods for performing TBLC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report the diagnostic yield and safety of TBLC with different procedural techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Retrospective multicenter study of subjects who underwent TBLC for the diagnosis of diffuse parenchymal lung diseases (DPLDs). The procedure was performed using various methods: flexible or rigid bronchoscopy, with or without the use of fluoroscopy or occlusion balloon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 128 subjects (59% women) with a mean age of 48.9\u00a0years were included. The overall diagnostic yield of TBLC was 78.1%, with a definite diagnosis on multidisciplinary discussion made in 57 (44.5%) subjects. On a multivariate analysis, the diagnostic yield was associated with the number of biopsies taken {ajdusted odds ratio [AOR] [95% confidence interval (CI)], 2.17 [1.29\u20103.67]}. The incidence of pneumothorax was lower in subjects who underwent TBLC with fluoroscopic guidance (5.9% vs 20.9%), [AOR (95% CI), 0.26 (0.07\u20100.94)]. Moderate\u2010to\u2010severe bleeding occurred less frequently when an occlusion balloon was used [1.8% vs 35.7%; AOR (95% CI), 0.02 (0.001\u20100.18)], after adjusting for age, use of fluoroscopy, number of biopsies obtained and number of lobes sampled. Four deaths occurred; 2 because of acute exacerbation of idiopathic pulmonary fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transbronchial lung cryobiopsy was found to offer a reasonable yield in the diagnosis of DPLDs. The incidence of pneumothorax and moderate\u2010to\u2010severe bleeding was lower with the use of fluoroscopy and an occlusion balloon, respectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/crj.12734","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T02:52:35Z","timestamp":1509763955000},"page":"1711-1720","source":"Crossref","is-referenced-by-count":74,"title":["The safety and efficacy of different methods for obtaining transbronchial lung cryobiopsy in diffuse lung diseases"],"prefix":"10.1111","volume":"12","author":[{"given":"Sahajal","family":"Dhooria","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-0236","authenticated-orcid":false,"given":"Ravindra M.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Critical Care and Sleep Medicine Apollo Hospitals Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Allergy and Sleep Medicine Royal Care Hospital Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5330-6391","authenticated-orcid":false,"given":"Karan","family":"Madan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Sleep Disorders All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderpaul Singh","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vallandramam","family":"Pattabhiraman","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Allergy and Sleep Medicine Royal Care Hospital Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Critical Care and Sleep Medicine Apollo Hospitals Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahadevan","family":"Sivaramakrishnan","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Allergy and Sleep Medicine Royal Care Hospital Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2383-9437","authenticated-orcid":false,"given":"Anant","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Sleep Disorders All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanjit","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education and Research Chandigarh Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and Research Chandigarh Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-7668","authenticated-orcid":false,"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203987"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12770"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000272"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086716"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0711OC"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.09.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04488"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12827"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078674"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000366"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12296"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000246"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.173066"},{"key":"e_1_2_9_15_1","article-title":"Transbronchial lung cryobiopsy with two bronchoscopes: nec novum nec magna","author":"Dhooria S","year":"2017","journal-title":"J Bronchol Interv Pulmonol."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00148-2016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12322"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444089"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201610-829OC"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.177463"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0022"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.2.ats4-99"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000456671"},{"issue":"1","key":"e_1_2_9_27_1","first-page":"2","article-title":"Validation of transbronchial cryobiopsy in interstitial lung disease\u2014interim analysis of a prospective trial and critical review of the literature","volume":"33","author":"Hagmeyer L","year":"2016","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis."},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12261"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2009.09.012"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-171"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381921"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2015.02.001"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12207"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/20018525.2016.1274099"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000292"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447329"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.06.019"}],"container-title":["The Clinical Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcrj.12734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/crj.12734","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/crj.12734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T12:22:05Z","timestamp":1693830125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/crj.12734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,12]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/crj.12734"],"URL":"https:\/\/doi.org\/10.1111\/crj.12734","archive":["Portico"],"relation":{},"ISSN":["1752-6981","1752-699X"],"issn-type":[{"value":"1752-6981","type":"print"},{"value":"1752-699X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,12]]}}}