{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:52:49Z","timestamp":1778788369487,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The quality of tissue acquisition during endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) is a major determinant of the diagnostic yield of the procedure. In the tissue button (TB) technique, the retrieved cellular specimen is fixed in ethanol and subsequently scraped from slide using surgical blade into formaldehyde and processed like ordinary tissue biopsy thus potentially increasing its diagnostic value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To retrospectively evaluate the diagnostic yield of a TB technique in patients undergoing EBUS\u2010TBNA for various malignant and benign conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The diagnostic yield of specimen obtained by two methods (TB and traditional cell\u2010block technique) performed during the same procedure are outlined in 46 patients who underwent EBUS\u2010TBNA (median age\u2009=\u200965, range 19\u201085 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, in both malignant and benign conditions, TB resulted in clear diagnostic material in 43\/46 (93.4%) patients. Specifically, TB provided clear histological diagnosis of malignancy (either primary lung cancer or metastases from extra\u2010thoracic cancer) in 30\/46 (65.2%) patients and granulomatous inflammation in 11\/46 (23.9%) of patients. Only in two patients TB did not provide diagnostic material.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The newly introduced TB technique provides valuable histological diagnostic material during EBUS\u2010TBNA both malignant and benign conditions. Given its simplicity and its high diagnostic yield, TB should be considered to be used as one of the preferred specimen acquisition modalities during EBUS\u2010TBNA specimen processing. Direct comparison to alternative tissue processing techniques during EBUS\u2010TBNA should be explored in further randomized prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12741","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T06:32:53Z","timestamp":1510295573000},"page":"1802-1808","source":"Crossref","is-referenced-by-count":1,"title":["The diagnostic value of tissue button technique for specimen accusation during endobronchial ultrasound\u2010guided transbronchial fine\u2010needle aspiration"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4230-3985","authenticated-orcid":false,"given":"Oren","family":"Fruchter","sequence":"first","affiliation":[{"name":"Pulmonary Division Wolfson Medical Center Holon Israel"},{"name":"The Sackler School of Medicine Tel Aviv University, The Internal Medicine Division Tel Aviv 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