{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:55:13Z","timestamp":1760043313934,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During acute on chronic hypercarbic respiratory failure (AHRF), arterial pH is associated with non\u2010invasive ventilation (NIV) failure and mortality. Venous blood gas (VBG) has been proposed as a substitute for arterial blood gas, based on a good agreement between venous and arterial values. We assessed the predictive value of admission VBG on intubation rate, NIV failure and mortality during AHRF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review of inpatients admitted between 2009 and 2015 with AHRF who had VBG performed on admission. Demographic, clinical and biological data were collected throughout the hospital course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>196 patients were included and hospital survival was not significantly associated with initial venous pH, PCO<jats:sub>2<\/jats:sub> or \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/crj12746-math-0001.png\" xlink:title=\"urn:x-wiley:17526981:media:crj12746:crj12746-math-0001\"\/>. Patients requiring intubation had significantly lower venous pH [7.29 (7.24\u20137.33) vs 7.31 (7.28\u20137.36), <jats:italic>P<\/jats:italic>\u2009=\u2009.04] while venous PCO<jats:sub>2<\/jats:sub> and \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/crj12746-math-0002.png\" xlink:title=\"urn:x-wiley:17526981:media:crj12746:crj12746-math-0002\"\/> did not differ as compared to non\u2010intubated patients. Intubation within 48 h of admission was associated with significantly lower venous pH [7.28 (7.24\u20137.30) vs 7.32 (7.28\u20137.37), <jats:italic>P<\/jats:italic>\u2009=\u2009.002] and higher PCO<jats:sub>2<\/jats:sub> [72 (63\u201392) mm Hg vs 62 (52\u201375) mm Hg, <jats:italic>P<\/jats:italic>\u2009=\u2009.04]. Among 69 patients receiving NIV, there were no differences in venous pH [7.29 (7.25\u20137.31) vs 7.30 (7.27\u20137.35), <jats:italic>P<\/jats:italic>\u2009=\u2009.3] or PCO<jats:sub>2<\/jats:sub> [68 (44\u201374) mm Hg vs 70 (55\u201397) mm Hg, <jats:italic>P<\/jats:italic>\u2009=\u2009.23] associated with subsequent intubation. Using <jats:italic>c<\/jats:italic> statistics, we observed poor performances of venous pH, PCO<jats:sub>2<\/jats:sub> or \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/crj12746-math-0003.png\" xlink:title=\"urn:x-wiley:17526981:media:crj12746:crj12746-math-0003\"\/> for prediction of NIV failure, intubation or hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results do not support the use of VBG on admission as a predictor for NIV failure, intubation and mortality during AHRF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12746","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T15:21:02Z","timestamp":1511968862000},"page":"1849-1857","source":"Crossref","is-referenced-by-count":6,"title":["Is venous blood gas performed in the <scp>E<\/scp>mergency <scp>D<\/scp>epartment predictive of outcome during acute on chronic hypercarbic respiratory failure?"],"prefix":"10.1111","volume":"12","author":[{"given":"Lisa","family":"Domaradzki","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, 500 University Drive Hershey Pennsylvania 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahithi","family":"Gosala","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, 500 University Drive Hershey Pennsylvania 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Iskandarani","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Pennsylvania State University College of Medicine and Milton S Hershey Medical Center, 500 University Drive Hershey Pennsylvania 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