{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:26:48Z","timestamp":1760898408900,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine the correlation between asthma and hiatal hernia (HH) in patients with gastroesophageal reflux disease (GERD)\u2010related asthma requiring laparoscopic anti\u2010reflux surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and thirty\u2010six GERD patients with medically refractory asthma with (80 patients) or without HH (56 patients) were enrolled. Gastroesophageal reflux disease was assessed by endoscopy, esophageal manometry, reflux monitoring and symptom questionnaires, and treated with laparoscopic Nissen fundoplication (LNF) or LNF with concomitant hiatal hernia repair (LNF\u2010HHR). The outcome measures included patients' satisfaction and drug independence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with HH had lower esophageal sphincters (<jats:italic>P<\/jats:italic>\u2009=\u2009.005) and higher DeMeester scores (<jats:italic>P<\/jats:italic>\u2009=\u2009.014) than those without HH. After an average follow\u2010up of 24 months, symptom scores were significantly decreased from the preoperative values (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Compared to LNF, LNF\u2010HHR showed a better improvement in both esophageal and asthmatic symptoms (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001 and <jats:italic>P<\/jats:italic>\u2009=\u2009.016, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The patients with GERD with asthma have a high prevalence of HH. The presence of HH maybe correlated with asthma and severe GERD. Actively treating HH not only improved reflux, but also controlled asthma symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12748","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T15:21:32Z","timestamp":1511968892000},"page":"1858-1864","source":"Crossref","is-referenced-by-count":8,"title":["Contribution of hiatal hernia to asthma in patients with gastroesophageal reflux disease"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-4150","authenticated-orcid":false,"given":"Zhi\u2010Tong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology and GERD The First Affiliated Hospital, Zhengzhou University Zhengzhou Henan Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology and GERD The First Affiliated Hospital, 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