{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:17:24Z","timestamp":1791850644013,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a significant event that results in substantial mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We evaluated the effectiveness of the high flow nasal cannulae (HFNC) therapy in severe AECOPD with moderate hypercapnic acute respiratory failure (ARF) compared to non\u2010invasive ventilation (NIV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prospective observational trial was performed to compare the effectiveness between the HFNC and NIV in severe AECOPD with moderate hypercapnic ARF. The end point was the intubation rate and 30\u2010day mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two AECOPD patients enrolled during study periods. The median age was 73 (66.5\u201079)\u00a0years, and 57 patients (64.8%) were male. Forty\u2010four patients were assigned to HFNC, and 44 patients were assigned to NIV. The intubation rate at day 30 was 25.0% in the HFNC group and 27.3% in the NIV group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.857), and the 30\u2010day mortality was 15.9% in the HFNC group and 18.2% in the NIV group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.845). The pH (7.38\u00a0\u00b1\u00a00.59 vs 7.36\u00a0\u00b1\u00a00.10, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.295), PaO<jats:sub>2<\/jats:sub> (82.2\u00a0\u00b1\u00a024.9 vs 81.6\u00a0\u00b1\u00a021.7\u00a0mm Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.899) and PaCO<jats:sub>2<\/jats:sub> (46.8\u00a0\u00b1\u00a015.2 vs 51.7\u00a0\u00b1\u00a017.2\u00a0mm Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.160) after 6\u00a0hours and the pH (7.39\u00a0\u00b1\u00a00.07 vs 7.39\u00a0\u00b1\u00a00.08, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.743), PaO<jats:sub>2<\/jats:sub> (84.3\u00a0\u00b1\u00a018.5 vs 84.7\u00a0\u00b1\u00a023.2\u00a0mm Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.934) and PaCO<jats:sub>2<\/jats:sub> (47.0\u00a0\u00b1\u00a016.0 vs 49.6\u00a0\u00b1\u00a013.7\u00a0mm Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.422) after 24 hours were not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no difference of the 30\u2010day mortality and intubation rate between HFNC and NIV groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12772","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T09:37:05Z","timestamp":1517564225000},"page":"2046-2056","source":"Crossref","is-referenced-by-count":112,"title":["High flow nasal cannulae oxygen therapy in acute\u2010moderate hypercapnic respiratory failure"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-4882","authenticated-orcid":false,"given":"Myoung Kyu","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Gangwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehwa","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Gangwon South 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