{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:53:42Z","timestamp":1788263622624,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:italic>Pseudomonas aeruginosa<\/jats:italic> is the predominant pathogen responsible of chronic colonization of the airways in cystic fibrosis (CF) patients. There are few European data about antibiotic susceptibility evolution of <jats:italic>P aeruginosa<\/jats:italic> in CF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study is to evaluate the evolution of antibiotic resistance in the period 2010\u20102013 in CF patients chronically colonized by <jats:italic>P aeruginosa<\/jats:italic> and to highlight the characteristics of this evolution in patients younger than 20\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and microbiological data were extracted from two electronic databases and analyzed. Antibiotic resistance was defined according to European Committee of Antimicrobial Susceptibility Testing for levofloxacin, ciprofloxacin, meropenem, amikacin and ceftazidime. The between\u2010group comparison was drawn with the Chi\u2010square test for proportions, with the <jats:italic>T<\/jats:italic>\u2010test for unpaired samples for normally distributed data and with Mann\u2010Whitney test for non\u2010normally distributed data. Significancy was defined by <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven CF patients, including thirteen subjects aged less than 20\u00a0years, were enrolled. <jats:italic>P.. aeruginosa<\/jats:italic> antibiotic sensitivity decreased significantly for fluoroquinolones, mainly in patients aged &lt;20\u00a0years, while it increased for amikacin and colistin. The analysis of minimum inhibitory concentration confirmed these trends. In pediatric patients treated with more than three antibiotic cycles per year, greater resistance was found, except for amikacin and colistin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An evolution in <jats:italic>P aeruginosa<\/jats:italic> antibiotic resistances is observed in the 4\u2010year period studied. Responsible and informed use of antibiotics is mandatory in CF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12787","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T14:40:20Z","timestamp":1520001620000},"page":"2189-2196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Antibiotic resistance evolution of <i>Pseudomonas aeruginosa<\/i> in cystic fibrosis patients (2010\u20102013)"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5294-9301","authenticated-orcid":false,"given":"Francesca","family":"Lucca","sequence":"first","affiliation":[{"name":"Department of Woman's and Child's Health University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Guarnieri","sequence":"additional","affiliation":[{"name":"Department of Woman's and Child's Health University of Padova Padova 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