{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:58:10Z","timestamp":1770134290836,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify a predictor of relapse in interstitial pneumonia (IP) in patients with anti\u2010aminoacyl tRNA synthetase antibodies\u2010positive dermatomyositis (ARS\u2010DMIP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study comprised 27 ARS\u2010DMIP patients. We compared clinical and laboratory findings between the relapse and non\u2010relapse groups during 2 years after treatment initiation to find predictors of relapse in IP. Candidate predictors were further assessed by analysing the relationship with the relapse of IP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One patient with ARS\u2010DMIP died. About 7 (26.9%) of the remaining 26 patients with ARS\u2010DMIP had a relapse of IP. We found that the levels of serum Krebs von den Lungen\u20106 (KL\u20106) in the relapse group were significantly higher than those in the non\u2010relapse group at the time points before treatment (<jats:italic>P<\/jats:italic>\u2009=\u2009.046) and after treatments, including 6 (<jats:italic>P<\/jats:italic>\u2009=\u2009.004), 12 (<jats:italic>P<\/jats:italic>\u2009=\u2009.013), 18 (<jats:italic>P<\/jats:italic>\u2009=\u2009.003) and 24 months (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The KL\u20106 values that maximised the area under the ROC curve were 2347 U\/mL before treatment, 622 U\/mL after 6 months and 468 U\/mL after 12 months. The relapse rates after 104 weeks were significantly higher in patients with KL\u20106 levels \u22652400 U\/mL before treatment (<jats:italic>P<\/jats:italic>\u2009=\u2009.014), \u2265600 ng\/mL after 6 months (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.005) and \u2265470 U\/mL after 12 months (<jats:italic>P<\/jats:italic>\u2009=\u2009.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that the levels of KL\u20106 before and after treatment in ARS\u2010DMIP may represent the disease activity of IP, and they may be useful as the predictor of relapse in IP in patients with ARS\u2010DMIP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12797","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T06:45:35Z","timestamp":1523342735000},"page":"2235-2241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Potential of Krebs von den Lungen\u20106 as a predictor of relapse in interstitial pneumonia with anti\u2010aminoacyl tRNA synthetase antibodies\u2010positive dermatomyositis"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1754-8956","authenticated-orcid":false,"given":"Kentaro","family":"Isoda","sequence":"first","affiliation":[{"name":"Department of Rheumatology Yodogawa Christian Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (IV) Osaka Medical College Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (IV) Osaka Medical College Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Konma","sequence":"additional","affiliation":[{"name":"Department of 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