{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:24:25Z","timestamp":1740147865921,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:00:00Z","timestamp":1525996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In\u2010hospital outcomes following decisions of withholding or withdrawing in Intensive Care Unit (ICU) patients have been previously assessed, little is known about outcomes after ICU and hospital discharge. Our objective was to report the 6\u2010month outcomes of discharged patients who had treatment limitations in a general ICU and to identify prognostic factors of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected the data of patients discharged from the ICU for whom life support was withheld from 2009 to 2011. We assessed the survival status of all patients at 6 months post\u2010discharge and their duration of survival. Survivors and non\u2010survivors were compared using univariate and multivariate analyses by Cox's proportional hazard model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred fourteen patients were included. The survival rate at 6 months was 58.8%. Survival was associated with acute respiratory failure (48% vs 19%, <jats:italic>P<\/jats:italic>\u2009=\u2009.006), a history of COPD (40% vs 21%, <jats:italic>P<\/jats:italic>\u2009=\u2009.03) and a lower SAPS II score (44 vs 49, <jats:italic>P<\/jats:italic>\u2009=\u2009.006). We identified a history of COPD as a prognostic factor for survival in the multivariate analysis (HR\u2009=\u20092.1; IC 95% 1.02\u20104.36, <jats:italic>P<\/jats:italic>\u2009=\u2009.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A total of 58.8% of patients for whom life\u2010sustaining therapies were withheld in the ICU survived for at least 6 months after discharge. Patients with COPD appeared to have a significantly higher survival rate. The decision to withhold life support in patients should not lead to a cessation of post\u2010ICU care and to non\u2010readmission of COPD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12899","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T16:15:14Z","timestamp":1523895314000},"page":"2249-2256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["COPD is independently associated with 6\u2010month survival in patients who have life support withheld in intensive care"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-3613","authenticated-orcid":false,"given":"Adel","family":"Maamar","sequence":"first","affiliation":[{"name":"Medical intensive care unit H\u00f4pital Pontchaillou, CHU de Rennes, 2 rue Henri Le Guilloux 35033 Rennes Cedex 9 France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Centre Hospitalier de Saint\u2010Malo, 1 Rue de la Marne 35400 Saint\u2010Malo France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Fill\u00e2tre","sequence":"additional","affiliation":[{"name":"Medical intensive care unit H\u00f4pital Pontchaillou, CHU de Rennes, 2 rue Henri Le Guilloux 35033 Rennes Cedex 9 France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlad","family":"Botoc","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Centre Hospitalier de Saint\u2010Malo, 1 Rue de la Marne 35400 Saint\u2010Malo France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Le Tulzo","sequence":"additional","affiliation":[{"name":"Medical intensive care unit H\u00f4pital Pontchaillou, CHU de Rennes, 2 rue Henri Le Guilloux 35033 Rennes Cedex 9 France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Rennes 1 Rennes France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Rennes 1, Unit\u00e9 INSERM CIC 1414, IFR 140 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Gacouin","sequence":"additional","affiliation":[{"name":"Medical intensive care unit H\u00f4pital Pontchaillou, CHU de Rennes, 2 rue Henri Le Guilloux 35033 Rennes Cedex 9 France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Rennes 1 Rennes France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Rennes 1, Unit\u00e9 INSERM CIC 1414, IFR 140 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Marc","family":"Tadi\u00e9","sequence":"additional","affiliation":[{"name":"Medical intensive care unit H\u00f4pital Pontchaillou, CHU de Rennes, 2 rue Henri Le Guilloux 35033 Rennes Cedex 9 France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Rennes 1 Rennes France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Rennes 1, Unit\u00e9 INSERM CIC 1414, IFR 140 Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0B013E3181659096"},{"issue":"6","key":"e_1_2_9_3_1","first-page":"981","article-title":"End\u2010of\u2010life care in the intensive care unit. 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