{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:39:22Z","timestamp":1761129562903,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>China has a very high tuberculosis (TB) burden. The interferon\u2010gamma release assay (IGRA) is more specific for the diagnosis of latent tuberculosis infection (LTBI) than the tuberculin skin test, especially among populations with a high degree of coverage by the BCG vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the first screening of healthcare workers (HCW) for LTBI using the IGRA at a general hospital in Beijing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pilot screening program for LTBI was triggered by accidental contact between HCW and two patients with active TB in the emergency department (ED). Given the necessity of estimating the overall LTBI prevalence in the institution, a sample of 518 HCW was enrolled in our cross\u2010sectional study. The second IGRA was repeated with 43 of the 121 HCW in the ED after exposure to index TB cases. Data on putative risk factors were collected with a self\u2010administered questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of LTBI in the targeted population was 21.8%. Differences in the prevalence of LTBI were significantly related to age, employment duration, and history of occupational exposure. A lack of childhood BCG vaccination was independently associated with the prevalence of LTBI (adjusted OR: 1.686, 95% CI: 1.045\u20102.723, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.0325). No new LTBI was diagnosed 12 weeks postexposure. No HCW adopted the preventive treatment for LTBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Considering the high morbidity of LTBI among HCW even in general hospitals, it is essential to formulate government policies and institutional operation protocols for the systematic screening, registration, and administration of prophylaxes for the control of LTBI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12960","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T06:09:59Z","timestamp":1540534199000},"page":"2581-2589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["First assessment of interferon gamma release assay results among healthcare workers at a general hospital in China"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-3111","authenticated-orcid":false,"given":"Li Ping","family":"Guo","sequence":"first","affiliation":[{"name":"Nosocomial Infection Control Office of China\u2010Japan Friendship Hospital Beijing China"},{"name":"Hospital Management Institute Beijing University of Chinese Medicine Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hospital Management Institute Beijing University of Chinese Medicine Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases of China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-4939","authenticated-orcid":false,"given":"Bin","family":"Cao","sequence":"additional","affiliation":[{"name":"Nosocomial Infection Control Office of China\u2010Japan Friendship Hospital Beijing China"},{"name":"Department of Clinical Microbiology and Infectious Diseases of China\u2010Japan Friendship Hospital Beijing China"},{"name":"National Clinical Research Centre of Respiratory Diseases, Centre for Respiratory Diseases, Department of Pulmonary and Critical Care Medicine China\u2010Japan Friendship Hospital Beijing China"},{"name":"Department of Pulmonary Medicine Capital Medical University Beijing 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infection.2015.https:\/\/www.who.int\/tb\/publications\/ltbi_document_page\/en\/."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2017.01.014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx137"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.56.7533"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164034"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030494"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12995-016-0117-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058202"},{"key":"e_1_2_9_17_1","unstructured":"World Health Organization.Checklist for Periodic Evaluation of TB Infection Control in Health\u2010Care Facilities.Geneva:WHO;2015.https:\/\/www.who.int\/tb\/areas-of-work\/preventive-care\/checklist_for_periodic_evaluation_of_tb_infection_control_in_health_facilities."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30227-X"},{"key":"e_1_2_9_19_1","unstructured":"General Office of the State Council of the People\u2019s Republic of China.The 13th Five\u2010Year National Tuberculosis Prevention and Control Scheme (2016\u20102020).https:\/\/www.gov.cn\/zhengce\/content\/2017-02\/16\/content_5168491.html[Chinese]."},{"issue":"1","key":"e_1_2_9_20_1","first-page":"16","article-title":"Related problems about latent tuberculosis infection among healthcare workers","volume":"39","author":"Pan","year":"2016","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"issue":"7","key":"e_1_2_9_21_1","first-page":"S22","article-title":"Use of interferon gamma release assay to assess latent tuberculosis infection among healthcare workers in Hong 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