{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T11:23:59Z","timestamp":1753356239036,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Technology Support Program","award":["2014BAI09B01"],"award-info":[{"award-number":["2014BAI09B01"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with small cell lung cancer (SCLC) younger than 40\u00a0years are limited in number. Our research aimed to assess the characteristics, diagnosis and outcomes of this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Records of patients under the age of 40 with SCLC at the Chinese Academy of Medical Sciences between January 2006 and December 2015 were reviewed and evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and three patients (67.0% limited stage, 33.0% extensive stage) were included, along with 54 (52.4%) never\u2010smokers. The median diagnostic interval and the median survival time (MST) were 51.0\u00a0days and 24.0\u00a0months, respectively. A total of 41 (39.8%) patients claimed to have undergone antibiotic treatment before diagnosis, with a median duration of 2\u00a0weeks. In univariate analysis, survival was better for the limited stage group than the extensive stage group (MST, 28.0 vs. 13.0\u00a0months, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Also, patients who received concurrent radiochemotherapy had better survival than those who received chemotherapy alone (MST, 29.0 vs. 18.0\u00a0months, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Patients with antibiotic treatment before SCLC diagnosis have worse prognosis than those without (MST, 21.0 vs. 27.0\u00a0months, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Moreover, a timely diagnosis (\u22641\u00a0month) exerted a positive impact on the overall survival in limited stage patients (48.0 vs. 26.0\u00a0months, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.047) and on progression\u2010free survival in extensive stage patients (6.0 vs. 3.0\u00a0months, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.030). Multivariate analysis suggested that disease stage, history of antibiotic treatment before SCLC diagnosis and performance status independently correlated with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study identified distinct characteristics and prognostic factors of SCLC patients under 40\u00a0years. More timely care may improve patient prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12986","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T14:23:31Z","timestamp":1545834211000},"page":"98-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Small cell lung cancer in the young: Characteristics, diagnosis and outcome data"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8450-7583","authenticated-orcid":false,"given":"Shiyu","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing 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