{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:53:44Z","timestamp":1776779624865,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Respiratory J"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There has been a rapid increase in the number of influenza and invasive pulmonary aspergillosis (IPA) co\u2010infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the risk factors and predictors of a poor prognosis in influenza and IPA co\u2010infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients with confirmed influenza during the 2017\u20102018 influenza season and cases of influenza and IPA co\u2010infection in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 64 patients with influenza infection were admitted to ICU. Of these patients, 18 were co\u2010infected with IPA. Others were assigned to the control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a046). A total of 45 patients from the literature were added to the IPA group (<jats:italic>n<\/jats:italic>\u00a0=\u00a063). A multivariate logistic regression suggested that influenza patients who were given steroids after ICU admission, who had a white blood count (WBC) of more than 10*10<jats:sup>9<\/jats:sup>\/L on ICU admission and whose CT findings manifested as multiple nodules and cavities might have a higher risk of developing IPA. Compared to survivors, non\u2010survivors had higher sequential organ failure assessment (SOFA) scores (16\u00a0\u00b1\u00a04 points vs 8\u00a0\u00b1\u00a04 points, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), lower CD4<jats:sup>+ <\/jats:sup>T cell counts on ICU admission [315 (83\u2010466) cells\/\u03bcL vs 152 (50\u2010220) cells\/\u03bcL, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.031] and more requirement extracorporeal membrane oxygenation (ECMO) support [13 (50%) vs 7 (18.9%), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Influenza patients who are given steroids after ICU admission, who have WBCs of greater than 10*10<jats:sup>9<\/jats:sup>\/L on ICU admission, and whose CT imaging shows multiple nodules and cavities might have a high risk of IPA. Higher SOFA scores, CD4<jats:sup>+ <\/jats:sup>T cell counts lower than 200 cells\/\u03bcL on ICU admission and more ECMO requirement might be predictors of a poor prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/crj.12995","type":"journal-article","created":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T10:44:11Z","timestamp":1547981051000},"page":"202-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Invasive pulmonary aspergillosis in patients with influenza infection: A retrospective study and review of the literature"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-8814","authenticated-orcid":false,"given":"Linna","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Centre for Respiratory Diseases, China\u2010Japan Friendship Hospital Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nannan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Centre for Respiratory Diseases, China\u2010Japan Friendship Hospital Beijing P.R. China"},{"name":"Peking Union Medical College Chinese Academy of Medical Sciences Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Centre for Respiratory Diseases, China\u2010Japan Friendship Hospital Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyu","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Centre for Respiratory Diseases, China\u2010Japan Friendship Hospital Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Centre for Respiratory Diseases, China\u2010Japan Friendship Hospital Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Centre for Respiratory Diseases, China\u2010Japan Friendship Hospital Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Centre for Respiratory Diseases, China\u2010Japan Friendship Hospital Beijing P.R. 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